New Alkaloids from Green Vegetable Soybeans and Their Inhibitory Activities on the Proliferation of Concanavalin A-Activated Lymphocytes

Journal of Agricultural and Food Chemistry
Taoyun WangShilin Yang

Abstract

A comprehensive phytochemical study of the chemical constituents of green vegetable soybeans resulted in the isolation of two new alkaloids, soyalkaloid A, 1, and isoginsenine, 2, together with four known ones, ginsenine, 3, (1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid, 4, (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid, 5, and indole-3-carboxylic acid, 6. The structures of compounds 1-6 were elucidated on the basis of spectroscopic and chemical analyses. All of the alkaloids were isolated from soybeans for the first time, and compound 1 was a new indole-type alkaloid with a novel carbocyclic skeleton. Their inhibitory activities on the proliferation of concanalin A-activated lymphocytes were assessed by CCK8 assay.

References

Dec 1, 2006·Journal of Asian Natural Products Research·J-Y WangX-W Yang
Apr 9, 2008·Immunology Letters·György NagyAndrew P Cope
Feb 22, 2012·Pediatrics and Neonatology·Ho-Chang KuoKai-Sheng Hsieh
Jan 15, 2013·Bioorganic & Medicinal Chemistry·Ruth GoldschmidtSidney M Hecht
Sep 2, 2015·Journal of Autoimmunity·Yogita Ghodke-Puranik, Timothy B Niewold

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Citations

Apr 19, 2018·Natural Product Research·Fen XiuDidier Stien
Jul 20, 2018·Natural Product Reports·Ashley C LindsayJonathan Sperry
Sep 9, 2017·Journal of the Science of Food and Agriculture·Taoyun WangShilin Yang
Dec 1, 2017·Journal of Agricultural and Food Chemistry·Xiuhua LanQiongming Xu
Feb 15, 2020·Journal of Agricultural and Food Chemistry·Pei-Feng ZhuXiao-Dong Luo

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