New alleles of Notch draw a blueprint for multifunctionality

Trends in Genetics : TIG
Alfonso Martinez Arias

Abstract

The Drosophila Notch protein is one of a family of receptors that mediate an essential and perhaps universal function in the assignation of cell fates during development. Activation of Notch by its ligand, Delta, leads to the cleavage of the intracellular domain of the receptor. This domain relocates to the nucleus, where it combines with the transcription factor Suppressor of Hairless to regulate gene expression. In a recent report, Ramain, Heitzler and colleagues reveal the existence of a second Notch signalling activity that is independent of Suppressor of Hairless and might be used to link Notch activity to that of other signalling pathways, most notably Wingless/Wnt signalling. This link might be a central element in many processes of cell-fate assignation during development.

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Citations

Apr 9, 2005·Pediatric Research·Joseph L Lasky, Hong Wu
Mar 15, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tim LangdonAlfonso Martinez Arias
Aug 2, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Penelope HaywardAlfonso Martinez Arias
Jan 5, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Silvia Muñoz-DescalzoAlfonso Martinez Arias
Jul 1, 2014·Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology·Beatriz LlamusíRubén Artero
Dec 4, 2012·Current Opinion in Genetics & Development·Jordi Garcia-Ojalvo, Alfonso Martinez Arias
Feb 14, 2012·Seminars in Cell & Developmental Biology·Silvia Muñoz Descalzo, Alfonso Martinez Arias
Nov 8, 2005·Structure·Mark E ZweifelDoug Barrick
Jun 5, 2003·Current Biology : CB·Graham Stone, Vernon French
Oct 23, 2004·Current Biology : CB·Steffen Scholpp, Michael Brand
Aug 8, 2006·Developmental Cell·Lea A GoentoroStanislav Y Shvartsman
Dec 14, 2011·Developmental Biology·Heather MarlowMark Q Martindale
Aug 19, 2008·Developmental Biology·Jeremiah J ZartmanStanislav Y Shvartsman
Jan 21, 2017·Scientific Reports·Md Zubbair MalikR K Brojen Singh
Feb 24, 2009·Physical Biology·C B MuratovS Y Shvartsman
Jun 2, 2006·Molecular Systems Biology·Jose M G Vilar
May 17, 2006·Technology in Cancer Research & Treatment·Joseph L Lasky, Linda M Liau
Jan 15, 2008·Development·Penelope HaywardAlfonso Martinez Arias

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