New ALS-Related Genes Expand the Spectrum Paradigm of Amyotrophic Lateral Sclerosis.

Brain Pathology
M SabatelliSerena Lattante

Abstract

Amyotrophic Lateral Sclerosis (ALS) is characterized by the degeneration of upper and lower motor neurons. Clinical heterogeneity is a well-recognized feature of the disease as age of onset, site of onset and the duration of the disease can vary greatly among patients. A number of genes have been identified and associated to familial and sporadic forms of ALS but the majority of cases remains still unexplained. Recent breakthrough discoveries have demonstrated that clinical manifestations associated with ALS-related genes are not circumscribed to motor neurons involvement. In this view, ALS appears to be linked to different conditions over a continuum or spectrum in which overlapping phenotypes may be identified. In this review, we aim to examine the increasing number of spectra, including ALS/Frontotemporal Dementia and ALS/Myopathies spectra. Considering all these neurodegenerative disorders as different phenotypes of the same spectrum can help to identify common pathological pathways and consequently new therapeutic targets in these incurable diseases.

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Citations

Jan 19, 2016·Brain Pathology·Caterina BendottiAntonio Migheli
Jan 6, 2017·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Michael J StrongMartin R Turner
Feb 19, 2020·Expert Review of Molecular Diagnostics·Filippo BaldacciHarald Hampel
Apr 25, 2020·The International Journal of Neuroscience·Jiajia ZhangZhenchang Zhang
May 28, 2020·International Journal of Molecular Sciences·Francesca TrojsiGioacchino Tedeschi
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Apr 28, 2020·Journal of the Neurological Sciences·João Pedro Nunes GonçalvesMarcondes C França

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