New amphiphilic glycopolymers by click functionalization of random copolymers - application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin.

Beilstein Journal of Organic Chemistry
Otman OtmanThierry Hamaide

Abstract

Glycopolymers with mannose units were readily prepared by click chemistry of an azido mannopyranoside derivative and a poly(propargyl acrylate-co-N-vinyl pyrrolidone). These glycopolymers were used as polymer surfactants, in order to obtain glycosylated polycaprolactone nanoparticles. Optimum stabilization for long time storage was achieved by using a mixture of glycopolymers and the non-ionic triblock copolymer Pluronic® F-68. The mannose moieties are accessible at the surface of nanoparticles and available for molecular recognition by concanavalin A lectin. Interaction of mannose units with the lectin were evaluated by measuring the changes in nanoparticles size by dynamic light scattering in dilute media.

References

Jan 1, 1978·Advances in Carbohydrate Chemistry and Biochemistry·I J Goldstein, C E Hayes
Feb 14, 2002·Chemical Reviews·Joseph J Lundquist, Eric J Toone
Apr 6, 2006·Journal of the American Chemical Society·Vincent LadmiralDavid M Haddleton

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Citations

May 9, 2013·Biomacromolecules·Anica LancuškiSébastien Fort
Nov 10, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Cédric TissandierThierry Hamaide

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Methods Mentioned

BETA
glycosylation
light scattering
NMR
dynamic light scattering

Software Mentioned

Pluronics

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