PMID: 6990949Apr 1, 1980Paper

New anaesthetic formulation for epicutaneous application tested for cutting split skin grafts

British Journal of Anaesthesia
L Ohlsén, S Englesson

Abstract

Ane-Pad (A 2358, Astra Lakemedel AB), a new local anesthetic formulation for application to the skin has been tested in the removal of split skin grafts. Ane-Pad is a thin cotton pad, containing a solution of 10% ketocaine base in a solvent mixture of isopropanol, glycerol and water. The pad has been used on the donor sites of 173 patients with a minimum application time of 1 h before surgery. Eighteen patients complained of slight, transient irritation immediately after application. After removal of the pad erythema was present in 39 patients and oedema in eight. In 157 patients (90.8%) analgesia was adequate. Two patients (1.1%) needed additional anaesthesia. The concentration of ketocaine in the blood was measured in 101 patients and did not exceed 850 ng ml--1. Therewere no systemic side-effects.

Citations

Sep 1, 1988·British Journal of Plastic Surgery·J SmallD F McCafferty
Nov 24, 2001·International Journal of Pharmaceutics·M CarafaG Lucania
Jan 1, 1973·Acta Anaesthesiologica Scandinavica. Supplementum·U Sjöstrand, B Widman
Jun 28, 1980·British Medical Journal·D Phelan, M MacEvilly
Jan 1, 1985·Scandinavian Journal of Plastic and Reconstructive Surgery·L OhlsénH Evers
Dec 1, 1982·Acta Anaesthesiologica Scandinavica·G M Ehrenström Reiz, S L Reiz
Apr 8, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M VerleyeJ M Gillardin

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