New and emerging strategies for reducing cardiometabolic risk factors

Pharmacotherapy
Philip T Rodgers, Dawn C Fuke

Abstract

Several new drug therapies with beneficial effects on more than one of the cardiometabolic risk factors that contribute to the metabolic syndrome have been developed recently or are under investigation. Emerging risk factors for coronary heart disease (CHD), including low concentrations of high-density lipoprotein (HDL) cholesterol and apolipoprotein A-1 (apoA-1), high levels of high-sensitivity C-reactive protein, and small dense low-density lipoprotein cholesterol particles, have been identified. We provide a detailed description of the mechanisms of action and findings from clinical trials of the new drug therapies and discuss established drug therapies with beneficial effects on emerging risk factors for CHD. The new and emerging drug therapies include an antiobesity agent that reduces atherogenic dyslipidemia and abnormal glucose metabolism; cholesteryl ester transfer protein inhibitors that increase HDL cholesterol and apoA-1 levels; glitazars that increase HDL cholesterol and decrease triglyceride concentrations, as well as improve abnormal glucose metabolism; and the amylin analog pramlintide and the incretin mimetic exenatide, both of which reduce body weight as well as improve abnormal glucose metabolism. The insulin-...Continue Reading

References

Aug 12, 1999·The New England Journal of Medicine·R H Knopp
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jun 30, 2001·The New England Journal of Medicine·P M RidkerUNKNOWN Air Force/Texas Coronary Atherosclerosis Prevention Study Investigators
Oct 26, 2001·JAMA : the Journal of the American Medical Association·S YusufUNKNOWN HOPE Study Investigators
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Dec 31, 2002·Journal of the American College of Cardiology·Michael H DavidsonEnrico P Veltri
Mar 14, 2003·The American Journal of Cardiology·Harold E BaysUNKNOWN ADvicor Versus Other Cholesterol-Modulating Agents Trial Evaluation
Jun 24, 2003·The American Journal of Cardiology·Samy I McFarlaneJames R Sowers
Sep 30, 2003·Diabetes Care·Daniel J Drucker
Nov 6, 2003·JAMA : the Journal of the American Medical Association·Steven E NissenRichard Kerensky
Jan 24, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Ronald W ClarkMark J Bamberger
Apr 6, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Martin C MichelUwe Heemann
Apr 9, 2004·The New England Journal of Medicine·H Bryan Brewer
Apr 9, 2004·The New England Journal of Medicine·Margaret E BrousseauDaniel J Rader
Apr 20, 2004·Obesity Research·Priscilla HollanderChristian Weyer
Oct 27, 2004·Diabetes Care·John B BuseUNKNOWN Exenatide-113 Clinical Study Group

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Citations

May 3, 2008·Clinical Cornerstone·Christopher P Cannon
Aug 10, 2007·International Journal of Clinical Practice·Anthony S Wierzbicki
Apr 24, 2007·BMC Psychiatry·Manit SrisurapanontNgamwong Jarusuraisin
Aug 31, 2007·Clinical and Experimental Hypertension : CHE·Firas YounisTalma Rosenthal
Feb 19, 2009·Clinical Transplantation·Milan LuknarJuraj Fabian

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