New and emerging treatments for vaso-occlusive pain in sickle cell disease

Expert Review of Hematology
Carlton Dampier

Abstract

Introduction: Acute pain from episodic vaso-occlusion (VOC) spans the lifespan of almost everyone with sickle cell disease (SCD), while additional chronic pain develops in susceptible individuals in early adolescences. Frequent acute pain with chronic pain causes significant physical and psychological morbidity, and frequent health-care utilization. Available pharmacologic therapies reduce acute pain frequency but few evidence-based therapies are available for chronic pain. Areas covered: An extensive PubMed literature search was performed with appropriate search criteria. The pathophysiology of acute pain from VOC in SCD is very complex with many events subsequent to sickle polymer formation. Sensitization of pain pathways and alterations of brain networks contributes to the experience of chronic pain. Numerous therapies targeting putative VOC mechanisms are in clinical trials, and show considerable promise. Alternative analgesic treatments for acute and chronic pain have been examined in small patient cohorts, but formal clinical trials are lacking. Expert opinion: Childhood is likely a critical window for prevention of acute and later chronic pain. New multimodal analgesic therapies are needed, particularly for chronic pain,...Continue Reading

References

Apr 1, 1992·Archives of Disease in Childhood·K BaileyG R Serjeant
Jul 4, 1991·The New England Journal of Medicine·O S PlattT R Kinney
Oct 1, 1990·Journal of Pediatric Psychology·G A Walco, C D Dampier
Mar 21, 1974·The New England Journal of Medicine·P N GilletteA Cerami
Aug 1, 1974·Annals of Internal Medicine·C M PetersonR Grady
Oct 28, 1971·The New England Journal of Medicine·P R McCurdy, L Mahmood
Dec 1, 1983·American Journal of Hematology·S CharacheW G Walker
Nov 13, 1980·The New England Journal of Medicine·R M RosaF H Epstein
Jun 9, 1994·The New England Journal of Medicine·O S PlattP P Klug
Aug 10, 2000·The Journal of Clinical Investigation·D K Kaul, R P Hebbel
Dec 21, 2000·British Journal of Haematology·C R MorrisL A Styles
Feb 13, 2001·British Journal of Haematology·R L Nagel, M E Fabry
Dec 19, 2001·The Journal of Biological Chemistry·Donald B Jump
Feb 15, 2002·Current Opinion in Hematology·Paul S Frenette
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Aslihan TurhanPaul S Frenette
Apr 23, 2002·Anaesthesia·M A Rose, P C A Kam
Oct 24, 2002·Blood·Neil M MatsuiStephen H Embury
Nov 20, 2002·Journal of Pediatric Hematology/oncology·Carlton DampierPatricia O'Neal
Jun 19, 2004·Hematology·Paul Brown BodhiseSamir K Ballas
Nov 25, 1949·Science·L PAULING, H A ITANO
Feb 3, 2005·British Journal of Haematology·Osheiza AbdulmalikToshio Asakura
May 7, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Hongmei RenMichael Crawford
May 10, 2005·Arthritis and Rheumatism·Thorsten GieseckeDaniel J Clauw
Sep 22, 2005·British Journal of Haematology·Jo HowardSally C Davies
Sep 7, 2006·Nature Reviews. Drug Discovery·Oleg V EvgenovJohannes-Peter Stasch
Nov 10, 2006·The New England Journal of Medicine·Ferid Murad
Jan 11, 2007·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Saunjoo L Yoon, Shakera Black
Jan 26, 2007·The West Indian Medical Journal·J Knight-MaddenI R Hambleton
Mar 29, 2007·Current Psychiatry Reports·Tami D BentonKim Smith-Whitley
Aug 25, 2007·Nature Reviews. Immunology·Klaus LeySussan Nourshargh
Jan 16, 2008·Annals of Internal Medicine·Wally R SmithSusan D Roseff
Jan 17, 2008·Progress in Lipid Research·Gerd Schmitz, Josef Ecker
May 16, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Alan A Wanderer
Aug 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Guillaume LettreStuart H Orkin
Oct 18, 2008·Annals of Emergency Medicine·Imoigele P AisikuJohn D Roberts

❮ Previous
Next ❯

Citations

May 14, 2020·Pediatric Hematology and Oncology·Andrew B CollinsSara E Williams
Dec 5, 2020·Journal of Clinical Medicine·Donovan A ArguetaKalpna Gupta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.