New and expanding ventricular hemorrhage predicts poor outcome in acute intracerebral hemorrhage

Neurology
Vignan Yogendrakumarthe PREDICT/Sunnybrook CTA Study Group

Abstract

To describe the relationship between intraventricular hemorrhage (IVH) expansion and long-term outcome and to use this relationship to select and validate clinically relevant thresholds of IVH expansion in 2 separate intracerebral hemorrhage (ICH) populations. We used fractional polynomial analysis to test linear and nonlinear models of 24-hour IVH volume change and clinical outcome with data from the Predicting Hematoma Growth and Outcome in Intracerebral Hemorrhage Using Contrast Bolus CT (PREDICT)-ICH study. The primary outcome was poor clinical outcome (modified Rankin Scale [mRS] score 4-6) at 90 days. We derived dichotomous thresholds from the selected model and calculated diagnostic accuracy measures. We validated all thresholds in an independent single-center ICH cohort (Massachusetts General Hospital). Of the 256 patients from PREDICT, 127 (49.6%) had an mRS score of 4 to 6. Twenty-four-hour IVH volume change and poor outcome fit a nonlinear relationship, in which minimal increases in IVH were associated with a high probability of an mRS score of 4 to 6. IVH expansion ≥1 mL (n = 53, sensitivity 33%, specificity 92%, adjusted odds ratio [aOR] 2.68, 95% confidence interval [CI] 1.11-6.46) and development of any new IVH (...Continue Reading

References

Dec 22, 1999·International Journal of Epidemiology·P RoystonW Sauerbrei
Jan 4, 2003·Stroke; a Journal of Cerebral Circulation·Daniel SchlegelScott E Kasner
Feb 25, 2005·The New England Journal of Medicine·Stephan A MayerUNKNOWN Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators
Apr 9, 2008·Lancet Neurology·Craig S AndersonUNKNOWN INTERACT Investigators
May 16, 2008·The New England Journal of Medicine·Stephan A MayerUNKNOWN FAST Trial Investigators
Feb 28, 2009·Stroke; a Journal of Cerebral Circulation·Daniel F Hanley
Dec 18, 2010·Stroke; a Journal of Cerebral Circulation·Zhi ChenGuohua Xi
Feb 25, 2011·Neurology·D DowlatshahiUNKNOWN VISTA Collaboration
May 26, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Jayme C KosiorUNKNOWN PREDICT/Sunnybrook CTA ICH study investigators
Nov 10, 2011·Neurosurgery·Jennifer JaffeIssam A Awad
Dec 17, 2011·Lancet Neurology·Joyce S Balami, Alastair M Buchan
May 17, 2012·Stroke; a Journal of Cerebral Circulation·Dar DowlatshahiUNKNOWN PREDICT/Sunnybrook ICH-CTA study group
May 30, 2013·The New England Journal of Medicine·Craig S AndersonUNKNOWN INTERACT2 Investigators
Aug 29, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Atte MeretojaStephen M Davis
Jun 9, 2016·The New England Journal of Medicine·Adnan I QureshiUNKNOWN ATACH-2 Trial Investigators and the Neurological Emergency Treatment Trials Network
Feb 16, 2016·Stroke and Vascular Neurology·Yaoyao BuFeng Gao

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Citations

Feb 23, 2020·Stroke; a Journal of Cerebral Circulation·Vignan YogendrakumarUNKNOWN PREDICT/Sunnybrook CTA Study Group
Nov 3, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Ronda LunDar Dowlatshahi
Mar 13, 2021·Current Neurology and Neuroscience Reports·Xin-Ni LvQi Li
Mar 25, 2021·Stroke and Vascular Neurology·Ronda LunDar Dowlatshahi
May 4, 2021·Neurological Research and Practice·Jens WitschHagen B Huttner
Jun 20, 2021·Neurology·Vignan YogendrakumarDar Dowlatshahi

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