PMID: 1511Dec 1, 1975

New and expedient determination of atenolol in biological samples

Journal of Pharmaceutical Sciences
J O Malbica, K R Monson

Abstract

A method is described for the GLC determination of atenolol BP in plasma and urine. Extraction is accomplished under dehydrating conditions, and interfering impurities are removed by using an acidified cyclohexane-isopropanol mixture (2:1) and charcoal-treated paper disks. The drug thus isolated appears to react more efficiently with heptafluorobutyric anhydride, increasing the sensitivity of GLC electron-capture analysis. Concentrations as low as 0.02 mug/ml were measured using 0.5-ml aliquots of plasma or 0.1 ml of urine. Amino alcohols such as atenolol may form hydrates or alcoholates, precluding complete derivatization with heptafluorobutyric anhydride.

Citations

May 17, 1978·European Journal of Clinical Pharmacology·J D FitzgeraldJ McAinsh
Jan 1, 1982·European Journal of Drug Metabolism and Pharmacokinetics·W Kirch, K G Görg
Jun 1, 1996·Journal of Pharmaceutical and Biomedical Analysis·F C ChengL C Chang
Jun 1, 1979·British Journal of Clinical Pharmacology·S H WanR F Maronde
Jul 1, 1978·Journal of Pharmaceutical Sciences·O H WeddleW D Mason
Sep 1, 1978·Journal of Pharmaceutical Sciences·S H WanS B Matin
Jan 1, 2011·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Mohamed S ElgawishAbdalla A Elshanawane
Dec 1, 1980·Clinical Science·M M IbrahimR Mossallam

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