New and future strategies to improve asthma control in children

The Journal of Allergy and Clinical Immunology
William C Anderson, Stanley J Szefler

Abstract

Symptomatic asthma in childhood has lifelong effects on lung function and disease severity, emphasizing the need for improved pediatric asthma control. Control of pediatric risk and impairment domains can be achieved through increased medication adherence or new therapeutic strategies. Developing electronic monitoring device technology with reminders might be a key noninvasive resource to address poor adherence in children and adolescents in a clinical setting. In patients who have persistently poor control despite optimal medication compliance, newly emerging pharmaceuticals, including inhaled therapies and biologics, might be key to their treatment. However, barriers exist to their development in the pediatric population, and insights must be drawn from adult studies, which has its own unique limitations. Biomarkers to direct the use of such potentially expensive therapies to those patients most likely to benefit are imperative. In this review the current literature regarding strategies to improve pediatric asthma control is addressed with the goal of exploring the potential and pitfalls of strategies that might be available in the near future.

References

Dec 2, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·B BenderM Z Wamboldt
May 23, 2002·American Journal of Respiratory and Critical Care Medicine·Richard J MartinChristine A Sorkness
Jul 3, 2002·Pediatrics·Laurie J BaumanCynthia M Visness
Jul 9, 2002·Allergy·Stéphanie Romanet-ManentUNKNOWN EGEA Cooperative Group
Apr 15, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S T HolgateUNKNOWN Omalizumab 011 International Study Group
Oct 27, 2004·American Journal of Respiratory and Critical Care Medicine·Paul M O'ByrneEric D Bateman
Jan 31, 2006·Lancet·Hans Bisgaard, Stan Szefler
May 12, 2006·The New England Journal of Medicine·Theresa W GuilbertFernando D Martinez
May 17, 2006·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Julian F GuestMark J Greener
Nov 8, 2006·The Journal of Allergy and Clinical Immunology·Robert C StrunkUNKNOWN CAMP Research Group
Dec 5, 2006·The Journal of Allergy and Clinical Immunology·Christine A SorknessUNKNOWN Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute
Feb 27, 2007·The Journal of Allergy and Clinical Immunology·Thomas CharlesShaun Holt
Sep 18, 2007·American Journal of Respiratory and Critical Care Medicine·Patrick Flood-PageUNKNOWN International Mepolizumab Study Group
Apr 4, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K ChibanaH W Chu
Oct 7, 2008·The New England Journal of Medicine·Donald P TashkinUNKNOWN UPLIFT Study Investigators
Mar 7, 2009·The New England Journal of Medicine·Pranabashis HaldarIan D Pavord
Mar 7, 2009·The New England Journal of Medicine·Parameswaran NairPaul M O'Byrne
Jun 2, 2009·American Journal of Respiratory and Critical Care Medicine·Prescott G WoodruffJohn V Fahy
Oct 21, 2009·The European Respiratory Journal·A R SmythP J Merkus
Nov 7, 2009·American Journal of Respiratory and Critical Care Medicine·Wendy C MooreUNKNOWN National Heart, Lung, and Blood Institute's Severe Asthma Research Program
Nov 17, 2009·The Journal of Allergy and Clinical Immunology·Bob LanierCarlos Fernandez Vidaurre
Feb 6, 2010·American Journal of Respiratory and Critical Care Medicine·Raed A DweikUNKNOWN National Heart, Lung, and Blood Institute Severe Asthma Research Program
Feb 23, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Scott W BurgessSunalene G Devadason
Mar 4, 2010·The New England Journal of Medicine·Robert F LemanskeUNKNOWN Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute
Oct 29, 2010·The New England Journal of Medicine·Stephen P PetersUNKNOWN National Heart, Lung, and Blood Institute Asthma Clinical Research Network
Jan 5, 2011·The Journal of Allergy and Clinical Immunology·Anne M FitzpatrickUNKNOWN National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program
Mar 18, 2011·The New England Journal of Medicine·William W BusseChristine A Sorkness
Jun 4, 2011·The Journal of Allergy and Clinical Immunology·Huib A M KerstjensJan A van Noord
Jul 5, 2011·Paediatric Respiratory Reviews·Xiao Yan HeFang Wang
Aug 3, 2011·The Journal of Allergy and Clinical Immunology·Stephen T Holgate
Aug 9, 2011·The Journal of Allergy and Clinical Immunology·Theresa W GuilbertUNKNOWN Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute
Nov 23, 2011·The Journal of Allergy and Clinical Immunology·Jerry A KrishnanUNKNOWN Adherence Ancillary Study Group
Nov 25, 2011·The New England Journal of Medicine·Robert S ZeigerUNKNOWN CARE Network of the National Heart, Lung, and Blood Institute
Dec 6, 2011·Current Opinion in Pulmonary Medicine·Kristin Kuhl, Nicola A Hanania
Dec 27, 2011·The Journal of Allergy and Clinical Immunology·Stanley J Szefler
Mar 14, 2012·The Journal of Allergy and Clinical Immunology·Jerry A KrishnanMichael Minnicozzi
Jun 12, 2012·Archives of Disease in Childhood·Malcolm BrodlieDavid A Spencer
Jul 25, 2012·Pediatrics·Florence T BourgeoisKenneth D Mandl
Jul 31, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Michelle N Eakin, Cynthia S Rand
Aug 4, 2012·The Journal of Allergy and Clinical Immunology·Guiquan JiaUNKNOWN Bronchoscopic Exploratory Research Study of Biomarkers in Corticosteroid-refractory Asthma (BOBCAT) Study Group
Sep 4, 2012·The New England Journal of Medicine·Huib A M KerstjensEric D Bateman
Sep 4, 2012·The New England Journal of Medicine·H William KellyUNKNOWN CAMP Research Group

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Citations

Apr 6, 2016·The Journal of Allergy and Clinical Immunology·Andrew G Weinstein
Apr 6, 2016·The Journal of Allergy and Clinical Immunology·William C Anderson, Stanley J Szelfer
May 9, 2016·The Journal of Allergy and Clinical Immunology·Cezmi A Akdis, Zuhair K Ballas
Jul 19, 2016·Advances in Pediatrics·Monica J FedericoStanley J Szefler
Jul 13, 2016·Immunology and Allergy Clinics of North America·Xiao Chloe Wan, Prescott G Woodruff
Aug 24, 2016·The World Allergy Organization Journal·Elham HossnyPeter Le Souef
Aug 9, 2016·The Journal of Allergy and Clinical Immunology·Andrew H LiuStanley J Szefler
Sep 11, 2016·Current Allergy and Asthma Reports·Hern-Tze Tina TanCezmi A Akdis
Sep 13, 2016·Expert Opinion on Drug Metabolism & Toxicology·Maria Gabriella MateraMario Cazzola
Feb 13, 2017·The Journal of Allergy and Clinical Immunology·Stanley J SzeflerEckard Hamelmann
Mar 30, 2017·Expert Review of Clinical Immunology·Giorgio CiprandiFabio Luigi Massimo Ricciardolo
Feb 25, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Carolina Sanchez ArandaDirceu Solé
Jan 25, 2017·Current Opinion in Allergy and Clinical Immunology·Allan B Becker, Elissa M Abrams
Jan 25, 2017·Current Opinion in Allergy and Clinical Immunology·William C Anderson
Oct 6, 2017·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·P W SullivanB Lanier
Dec 13, 2017·Acta Clinica Belgica·Kristine DesagerEddy Bodart
May 15, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y-L YehY L Lee
Nov 14, 2018·Current Opinion in Pulmonary Medicine·David L Peloza, Daniel J Jackson
Oct 20, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rodney D BrittY S Prakash
Jan 26, 2018·Drugs·Eckard Hamelmann, Stanley J Szefler
Sep 25, 2019·Expert Opinion on Investigational Drugs·Giancarlo MaroneGilda Varricchi
Nov 7, 2019·Current Opinion in Pulmonary Medicine·Silvia Sánchez-GarcíaJavier Domínguez-Ortega
Mar 7, 2020·Pediatric Pulmonology·Stanley J SzeflerWarren Lenney
Feb 10, 2016·Current Opinion in Allergy and Clinical Immunology·Gilda VarricchiGiorgio W Canonica
Jul 12, 2018·Current Allergy and Asthma Reports·August GenerosoJohn Oppenheimer
Feb 23, 2017·Current Opinion in Allergy and Clinical Immunology·Leonard B Bacharier, Stanley J Szefler
Jan 11, 2018·Current Medicinal Chemistry·Gilda VarricchiGianni Marone
Sep 27, 2018·Archivum Immunologiae Et Therapiae Experimentalis·Umut Can KucuksezerCezmi A Akdis
Oct 5, 2018·Pediatric Allergy, Immunology, and Pulmonology·Elissa M AbramsStanley J Szefler
Dec 13, 2016·Current Treatment Options in Allergy·Anna James, Gunilla Hedlin
Feb 25, 2017·Current Allergy and Asthma Reports·Regina K Rowe, Michelle A Gill
Jun 28, 2019·Journal of Paediatrics and Child Health·Philippa HarrisonAdrienne Moline
Jan 17, 2020·Pediatric Pulmonology·Heather Hoch De KeyserMonica J Federico
Nov 18, 2015·Current Opinion in Pulmonary Medicine·James Cook, Sejal Saglani
Oct 31, 2020·Journal of Applied Microbiology·L B de LacerdaC L Silva
Feb 6, 2021·Therapeutic Advances in Respiratory Disease·Deyu ZhaoQian Ni
May 30, 2021·International Journal of Nursing Studies·Hadassah Joann RamachandranWenru Wang
Aug 7, 2021·Journal of Behavioral Medicine·Rachel SweenieDavid A Fedele

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