New and investigational antiepileptic drugs

Expert Opinion on Investigational Drugs
Pasquale Striano, Salvatore Striano

Abstract

In the last fifteen years, new antiepileptic medications have been offered for the treatment of patients with epilepsy. Nevertheless, despite optimal medical treatment, up to 30% of patients still experience recurrent seizures and the challenge for new, more efficacious and better-tolerated drugs continues. New antiepileptic drugs include the evolution of pre-existing drugs and new compounds identified through the investigation of additional molecular targets, such as SV2A synaptic vesicle protein, voltage-gated potassium channels, ionotropic and metabotropic glutamate receptors, and gap junctions. This paper reviews the available information on various classes of molecules that are in the pipeline as well as on the innovative approaches to the treatment of epilepsy.

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Citations

Aug 7, 2010·Nature Reviews. Neurology·Pasquale Striano, Carlo Minetti
Mar 17, 2010·Epilepsy Currents·Chrysanthy Ikonomidou
May 15, 2013·Expert Opinion on Pharmacotherapy·Pasquale Striano, Vincenzo Belcastro
Apr 16, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pasquale StrianoFederico Zara
Oct 19, 2016·Clinical Neuropharmacology·Pasquale StrianoSalvatore Striano
Jan 10, 2017·Expert Opinion on Pharmacotherapy·Pasquale Striano, Vincenzo Belcastro
Mar 11, 2017·Nature Reviews. Neurology·Pasquale Striano, Federico Zara
May 12, 2010·Pharmaceuticals·Dana Ekstein, Steven C Schachter
Dec 29, 2020·Frontiers in Pharmacology·Sara DuboisPasquale Striano
Mar 10, 2011·Current Opinion in Neurology

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