PMID: 9431571Feb 7, 1998Paper

New and traditional approaches for the assessment of testicular toxicity

Reproductive Toxicology
L SuterR Bechter

Abstract

In this study, the suitability of several methods for the assessment of testicular damage, including histopathology, flow cytometry (FCM), testicular sperm head counts, and secretion of androgen binding protein (ABP), has been evaluated. Testicular toxicity after acute exposure of adult rats to different doses of the known toxicant 1,3-dinitrobenzene (DNB) was analyzed. The effects showed dose dependence, in spite of the large variability within each dose group. Histopathology and FCM showed germ cell depletion, particularly of round spermatids; testicular sperm head counts were reduced and ABP production was increased. All evaluated methods showed similar sensitivities. The increased testicular ABP levels support the theory that the Sertoli cell is the likely target of DNB induced testicular toxicity, producing subsequent germ cell depletion. The presented results show the suitability of FCM for the analysis of testicular damage and also support the usefulness of including a metabolic marker for Sertoli cell function.

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Citations

Sep 27, 2005·Contraception·Maria Elsa TrainaMarcello Spanò
Jan 1, 2003·Reproductive Toxicology·Maria Elsa TrainaMarcello Spanò
Jul 14, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Naomi D ElkinRichard M Sharpe
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Mar 26, 2003·The Journal of Veterinary Medical Science·Chang Yong YoonCheol Kyu Kim
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Mar 14, 2002·Toxicologic Pathology·Danielle RomanPaul-Georg Germann

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