New anti-angiogenic leading structure discovered in the fruit of Cimicifuga yunnanensis

Scientific Reports
Yin NianMinghua Qiu

Abstract

Cimyunnins A-C (1-3), characterized with an unusual fused cyclopentenone ring G, together with cimyunnin D (4), possessing a highly rearranged γ-lactone ring F, were characterized from the fruit of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic analysis, X-ray diffraction, and density functional theory calculations. In addition, cimyunnin A exhibited comparable anti-angiogenic activities to those of sunitinib, a clinically-used first-line angiogenesis inhibitor, in the in vitro and ex vivo studies.

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Citations

Sep 15, 2016·Expert Review of Hematology·E Carlos Rodriguez-Merchan
Feb 15, 2020·Natural Product Reports·Robert A Hill, Joseph D Connolly
Apr 5, 2018·Frontiers in Chemistry·Haishan LiuWeiming Zhu
May 14, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zhi ChenQinghao Guo
Jul 3, 2021·Marine Drugs·Valery M DembitskyVladimir V Poroikov
Jul 26, 2018·The Journal of Organic Chemistry·Qiang-Qiang ShiMing-Hua Qiu

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Methods Mentioned

BETA
NMR
X-ray
Assay

Software Mentioned

SHELXS
Gaussian
Maestro7
97

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