New antibacterial and cytotoxic activities of falcarindiol isolated in Crithmum maritimum L. leaf extract

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Laetitia Meot-DurosChristian Magné

Abstract

Bioassay-guided fractionation of a chloroformic extract obtained from Crithmum maritimum leaves led to the chemical isolation of falcarindiol, a polyacetylene widely distributed within the Apiaceae family. Structure of this compound was confirmed by NMR and activity was tracked using a screening microplate bioassay. Falcarindiol strongly inhibited the growth of Micrococcus luteus and Bacillus cereus, with a minimum inhibitory concentration (MIC) value of 50 microg ml(-1). Moreover, this compound showed cytotoxicity against IEC-6 cells with an IC50 value of 20 microM after 48 h of exposition. These results suggest that Crithmum maritimum could be potentially used in food manufactures and cosmetology as preservative agents and biopesticides, or in medicine as new antibiotics, confirming the interest in studying halophytic species as sources of bioactive compounds.

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Citations

Jul 31, 2013·Journal of Agricultural and Food Chemistry·Jun YoshidaKen-Ichi Kimura
Mar 22, 2012·Journal of Natural Products·Paulina WyrembekJerzy Wladyslaw Mozrzymas
Apr 17, 2015·Chemistry & Biodiversity·Yuemei ChenXingyun Chai
Mar 15, 2019·Natural Product Research·Shouwen ZhangJunwei He
Sep 4, 2014·Asian Pacific Journal of Tropical Biomedicine·Nirmal Kumar, Anil Kumar Singh
Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lars Porskjær Christensen
Dec 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ali MedbouhiAlain Muselli
Oct 12, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Kai WuWei-Hua Huang
May 1, 2021·Natural Product Research·Yan SunHai-Xue Kuang
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rocco GiordanoAllan Stensballe

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