New antibiotic structures from fermentations

Expert Opinion on Therapeutic Patents
Sheo B Singh, Katherine Young

Abstract

Fermentation-derived natural products have been a traditional source of antibiotics and antibiotic leads. Most of these discoveries were made about 50 years ago and continue to serve as leads for new antibiotics even today; however, their value as leads for new antibiotics is slowly fading away. In the last decade two novel classes of antibiotics were approved for clinical practice. One of them, daptomycin, is a natural product. This article provides a survey of patent literature, with supporting data from scientific literature wherever available, for antibiotics discovered during 2005 - 2009 from fermentations. Readers will gain an overview of the 44 new antibiotic structures reported from 16 organizations in the last 5 years. The most significant discoveries include platensimycin, platencin, amycolamicin and a number of thiazolyl peptides. Natural products continue to play significant role in the discovery of new antibiotics and clearly a renewed interest in the natural products discovery is warranted to discover novel antibiotics to fight drug resistant bacteria.

References

Jun 20, 2002·Journal of the American Chemical Society·Keith L ConstantineJohn E Leet
Nov 5, 2005·Organic Letters·Julian DaviesRaymond J Andersen
Jan 18, 2006·Biochemical Pharmacology·Sheo B Singh, John F Barrett
Feb 1, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·George H TalbotUNKNOWN Antimicrobial Availability Task Force of the Infectious Diseases Society of America
Nov 9, 2006·Chemistry : a European Journal·Ranjala RatnayakeRobert J Capon
Dec 13, 2006·Nature Reviews. Drug Discovery·David J PayneDavid L Pompliano
Apr 21, 2007·The Journal of Antibiotics·Noriyuki OkujoShinichi Kondo
Apr 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jun WangSheo B Singh
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Nov 24, 2007·Journal of the American Chemical Society·Kithsiri B HerathSheo B Singh
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brad SpellbergUNKNOWN Infectious Diseases Society of America
Apr 2, 2009·Journal of Natural Products·Chaowei ZhangSheo B Singh

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Citations

Sep 28, 2013·The Lancet Infectious Diseases·Emmanouil AngelakisDidier Raoult
Dec 2, 2010·The Journal of Antibiotics·Roberta PozziStefano Donadio
Sep 15, 2011·The Journal of Antibiotics·Evan Martens, Arnold L Demain
Jan 28, 2014·The Indian Journal of Surgery·Kamal KatariaAnita Dhar
Sep 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ruofeng ShangJiatu Wang
Jul 30, 2014·Internal Medicine Journal·N J ChavesK L Buising
Jul 22, 2014·Journal of Pharmaceutical and Biomedical Analysis·Matthias D'HondtBart De Spiegeleer
Jan 5, 2012·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hideki Hashizume

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