New antimicrobial bromotyrosine analogues from the sponge Pseudoceratina purpurea and its predator Tylodina corticalis

Marine Drugs
Michael P Gotsbacher, Peter Karuso

Abstract

Bioassay-guided fractionation of extracts from temperate Australian collections of the marine sponge Pseudoceratina purpurea resulted in the isolation and characterisation of two new and six known bromotyrosine-derived alkaloids with antibiotic activity. Surprisingly, a single specimen of the mollusc Tylodina corticalis, which was collected while feeding on P. purpurea, contained only a few of the compounds found in the sponge suggesting selective accumulation and chemical modification of sponge metabolites.

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Citations

Jan 14, 2017·Journal of Natural Products·Kavita RaginiPeter Karuso
Oct 27, 2016·Natural Product Reports·Zhong Jin
Sep 29, 2018·Natural Product Reports·Melany P PuglisiRyan Young
Apr 29, 2016·Proceedings. Biological Sciences·Robert A QuinnForest Rohwer
Mar 16, 2017·Natural Product Reports·John W BluntMichèle R Prinsep
Aug 22, 2018·Frontiers in Pharmacology·Celso AlvesRui Pedrosa
Dec 30, 2020·Marine Drugs·Conxita Avila, Carlos Angulo-Preckler
Dec 30, 2015·Bioorganic & Medicinal Chemistry Letters·Jingqiu DaiPhilip Williams

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Methods Mentioned

BETA
NMR
gel filtration
column chromatography

Software Mentioned

Class
VP
LCMSsolution
XCalibur2

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