New antimicrobial contact catalyst killing antibiotic resistant clinical and waterborne pathogens

Materials Science & Engineering. C, Materials for Biological Applications
A GuridiE Grohmann

Abstract

Microbial growth on medical and technical devices is a big health issue, particularly when microorganisms aggregate to form biofilms. Moreover, the occurrence of antibiotic-resistant bacteria in the clinical environment is dramatically growing, making treatment of bacterial infections very challenging. In search of an alternative, we studied a novel antimicrobial surface coating based on micro galvanic elements formed by silver and ruthenium with surface catalytic properties. The antimicrobial coating efficiently inhibited the growth of the nosocomial pathogens Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and Enterococcus faecium as demonstrated by the growth inhibition on agar surface and in biofilms of antibiotic resistant clinical E. faecalis, E. faecium, and S. aureus isolates. It also strongly reduced the growth of Legionella in a drinking water pipeline and of Escherichia coli in urine. We postulate a mode of action of the antimicrobial material, which is independent of the release of silver ions. Thus, the novel antimicrobial coating could represent an alternative to combat microbial growth avoiding the toxic side effects of high levels of silver ions on eukaryotic cells.

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Citations

Aug 2, 2017·Water Science and Technology : a Journal of the International Association on Water Pollution Research·C P TheologidesC N Costa
Dec 8, 2017·Biointerphases·Alexander HeissEvi Held-Föhn
Nov 1, 2017·Frontiers in Microbiology·Sandra Águila-ArcosItziar Alkorta
Feb 6, 2021·Biological Chemistry·Nico LinznerHaike Antelmann
Nov 5, 2020·International Journal of Molecular Sciences·Alexander I KostyukDmitry S Bilan

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