PMID: 9546919Jan 1, 1996Paper

New antithrombotics for the treatment of acute and chronic arterial ischemia

Vascular Medicine
J Hirsh

Abstract

The established antithrombotic agents are effective but they have limitations which have provided opportunities for the development of new antithrombotic compounds. Of these new agents, the antithrombin III-independent thrombin inhibitors and the platelet GPIIb/IIIa receptor antagonists are the most advanced in their development. Other new antithrombotic agents include the antithrombin III-independent factor Xa inhibitors, activated protein C, soluble thrombomodulin and tissue factor pathway inhibitor. Of the GPIIb/IIIa antagonists, the humanized 7E3 antibody and integrin have been evaluated in phase III studies. The 7E3 antibody was effective in preventing both short-term and longer-term complications of coronary angioplasty. The antithrombin III-independent thrombin inhibitors hirudin and hirulog have also been evaluated in phase III studies. The studies with hirudin as an adjuvant to coronary thrombolysis had to be terminated and restarted at lower dosages because of an unacceptable incidence at intracranial hemorrhage and the study with hirulog produced equivocal results.

References

Jan 1, 1979·Thrombosis Research·C Kettner, E Shaw
Jan 4, 1990·The New England Journal of Medicine·B S Coller
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P J Hogg, C M Jackson
Oct 9, 1986·The New England Journal of Medicine·C T ShermanL Morgenstern
Mar 1, 1985·Journal of the American College of Cardiology·J A AmbroseV Fuster
Jul 1, 1993·Journal of the American College of Cardiology·D L BrutsaertT C Gillebert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.