New antivirals for the treatment of chronic hepatitis B

Expert Opinion on Investigational Drugs
Vincent SorianoCarmen de Mendoza

Abstract

Current treatment with oral nucleos(t)ides entecavir or tenofovir provide sustained suppression of HBV replication and clinical benefit in most chronic hepatitis B virus (HBV) infected persons. However, HBV rebound generally occurs upon drug discontinuation due to persistence of genomic HBV reservoirs as episomic cccDNA and chromosomic integrated HBV-DNA. There is renewed enthusiasm on HBV drug discovery following recent successes with antivirals for hepatitis C and immunotherapies for some cancers. Areas covered: New drugs that target distinct steps of the HBV life cycle are been developed, including inhibitors of viral entry, new polymerase inhibitors, capsid and assembly inhibitors, virus release blockers, and disruptors of cccDNA formation and transcription. Alongside these antivirals, agents that enhance anti-HBV specific immune responses are being tested, including TLR agonists, checkpoint inhibitors and therapeutic vaccines. Expert opinion: The achievement of a 'functional cure' for chronic HBV infection, with sustained HBsAg clearance and undetectable viremia once medications are stopped, represents the next step in the pace towards HBV elimination. Hopefully, the combination of new drugs that eliminate or functionally ...Continue Reading

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Citations

May 3, 2018·Expert Opinion on Biological Therapy·Robert FlisiakMariusz Łucejko
Sep 29, 2018·Genes·Emilia Hadziyannis, Andreas Laras
Apr 11, 2019·European Journal of Gastroenterology & Hepatology·Vicente SorianoOctavio Corral
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Jul 11, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hong ZhangJunqi Niu
Jul 3, 2018·Journal of Medicinal Chemistry·Werner EmbrechtsDavid McGowan

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