New application method of fibrin glue for more effective hemostasis in cardiovascular surgery: rub-and-spray method

The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi
Naoki MinatoManabu Itoh

Abstract

This study was performed to determine the most effective application method of fibrin glue as a hemostatic sealant in cardiovascular surgery. The effectiveness of fibrin glue as a hemostatic sealant was compared between 4 methods of application; dripping, spray, spray-and-rub, and rub-and-spray methods. I. In vitro 'burst pressure' was measured in fibrin glue-sealed needle holes of polytetrafluoroethylene (PTFE) graft in each method. II. Fibrin glue-sealed needle holes of PTFE grafts implanted between an abdominal aorta and iliac arteries of a pig was microscopically examined to determine the effectiveness of fibrin glue sealing in each method. I. Burst pressures were 24.1 +/- 7.9 mmHg in dripping, 98.1 +/- 35.4 mmHg in spray, 140.8 +/- 34.8 mmHg in spray-and-rub and 206.7 +/- 26.1 mmHg in rub-and-spray method (statistically significant, p<0.01, between each method). II. Microscopically, no fibrin glue remained on the external surface of the PTFE graft in the dripping method. Fibrin glue plugged 1/3 or 2/3 of the depth of the needle hole in the spray method and spray-and-rub methods respectively. In the rub-and-spray method, fibrin glue covered the needle hole over the external surface of the graft, completely plugged the needl...Continue Reading

References

May 1, 1987·The Annals of Thoracic Surgery·J W BakerS P Nolan
Aug 1, 1982·The Thoracic and Cardiovascular Surgeon·H RedlH P Dinges
Aug 1, 1982·The Thoracic and Cardiovascular Surgeon·G WalterbuschH G Borst
Jan 1, 1997·The Journal of Surgical Research·J I ZargeH P Greisler

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Citations

Jun 15, 2010·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Motoyuki HisagiShunei Kyo
Mar 16, 2012·General Thoracic and Cardiovascular Surgery·Hajime KinHitoshi Okabayashi
Oct 12, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tsutomu MatsushitaTomoya Inoue
Aug 7, 2009·The Journal of Thoracic and Cardiovascular Surgery·Kazuhiro UedaKimikazu Hamano
Sep 26, 2015·Bio-medical Materials and Engineering·Keigo YamashitaShigeki Taniguchi
Jun 10, 2019·General Thoracic and Cardiovascular Surgery·Masaaki NaganumaYoshikatsu Saiki
Oct 22, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Noriko ShinyaTakamichi Shigaki

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