New application of dydrogesterone as a part of a progestin-primed ovarian stimulation protocol for IVF: a randomized controlled trial including 516 first IVF/ICSI cycles

Human Reproduction
Sha YuAi Ai

Abstract

Can dydrogesterone (DYG) be used as an alternative progestin in a progesterone primed ovarian stimulation (PPOS) protocol? DYG can be used as an appropriate alternative progestin in a PPOS protocol. PPOS is a new ovarian stimulation regimen based on a freeze-all strategy that uses progestin as an alternative to a GnRH analog for suppressing a premature LH surge during the follicular phase. Medroxyprogesterone acetate (MPA) has been successfully used as an adjuvant to gonadotrophin in the PPOS protocol. However, the use of MPA may lead to stronger pituitary suppression and thus may require a higher dosage of hMG and a longer duration of ovarian stimulation than that of conventional ovarian stimulation protocol. A prospective RCT including 516 patients was performed between November 2015 and November 2016. Computerized randomization was conducted to assign participants at a 1:1 ratio into two treatment groups: an hMG + DYG group (260 patients) or an hMG + MPA group (256 patients) followed by IVF or ICSI with the freeze-all strategy. One cycle per patient was included. The primary outcome of the trial was the number of oocytes retrieved. The sample size was chosen to detect a difference of two oocytes with a power of 90%. Patients...Continue Reading

References

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Citations

Apr 21, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Pinxiu HuangZhong Lin
May 8, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Francisca MartínezBuenaventura Coroleu
May 14, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Francisca MartínezNikolaos Polyzos
Dec 24, 2019·Human Reproduction Update·Yossi MizrachiAriel Weissman
Jul 1, 2020·Thyroid : Official Journal of the American Thyroid Association·Meng RaoShuhua Zhao
Sep 19, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Olesya BespalovaIgor Kogan
Sep 27, 2019·Frontiers in Medicine·Paul PirteaJean Marc Ayoubi
Dec 7, 2019·Journal of Gynecology Obstetrics and Human Reproduction·Zhenni MuYang Yi
Mar 5, 2021·Frontiers in Cell and Developmental Biology·Pavel DeryabinAleksandra Borodkina
Mar 21, 2021·Human Reproduction Update·Francisca MartinezNikolaos P Polyzos
Apr 25, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Kemal OzgurKevin Coetzee
May 5, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hulusi Bulent ZeynelogluTahir Eryılmaz

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