New approach on the development of a mucosal vaccine against strangles: Systemic and mucosal immune responses in a mouse model

Vaccine
H F FlorindoA J Almeida

Abstract

Streptococcus equi subspecies equi affects animals of Equidae family and is the causative agent of strangles, an acute, extremely contagious and deadly disease. Prolonged periods of protection associated to absence of serious adverse reactions were not yet achieved. Thus, this experimental work is focused on the study of mucosal, humoral and cellular immune responses developed in a mouse model, after the intranasal administration of S. equi antigens associated by adsorption or encapsulation to poly(lactic acid) nanospheres, modified by mucoadhesive polymers and absorption enhancers. Particles fitted the nanometer range and proteins integrity and antigenicity were not affected. PLA nanospheres induced a mixed Th1 and Th2 response, being therefore potential carriers for the delivery of S. equi antigens.

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Citations

Jul 31, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Miguel A RodriguesAntónio J Almeida
Jun 5, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Olga Kammona, Costas Kiparissides
Oct 15, 2009·International Journal of Pharmaceutics·H F FlorindoA J Almeida
Sep 8, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Burcu SayinOya H Alpar
Mar 17, 2015·International Journal of Pharmaceutics·Rania A H Ishak, Rihab Osman
Mar 26, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joana M SilvaHelena F Florindo
Nov 9, 2016·Acta Biomaterialia·Carina PeresHelena F Florindo
Apr 6, 2017·Journal of Microencapsulation·Liliana Aranha CaetanoL M D Gonçalves
Apr 4, 2013·Chemical Society Reviews·Mahmoud Elsabahy, Karen L Wooley
Dec 29, 2020·Biomaterials·David WibowoBernd H A Rehm
May 28, 2019·Biomacromolecules·Majela Gonzalez-MiroBernd H A Rehm

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