New approach to analyze genetic and clinical data in bisphosphonate-induced osteonecrosis of the jaw

Oral Diseases
B BallaP Lakatos

Abstract

Osteonecrosis of the jaw (ONJ) is a major complication associated with long-term use of bisphosphonates (BP). We aimed to investigate the effect of CYP2C8 rs1934951 SNP and its relationship to a number of clinical and biochemical factors in 46 Hungarian subjects with bisphosphonate-induced ONJ. Blood samples were collected from each subject and genomic DNA was extracted. SNP analysis of CYP2C8 gene was carried out by predesigned TaqMan primer/probe sets. The genetic data together with clinical and biochemical variables were evaluated by chi-square test, logistic regression, and principal component analysis (PCA). The risk of mandibular localization of ONJ was 19.2-fold higher in subjects with AG genotype than in normal GG genotype. PCA revealed strong positive correlations between maxillar localization of ONJ and a group of variables including intravenous BP application and serum lipid markers. Mandibular localization of ONJ was correlated positively with serum calcium, 25-hydroxy-vitamin D and PTH levels, oral BP application, and the length of BP therapy. The degree of the disease and the number of recurrences were correlated with the application of hormone-deprivation therapy for breast cancer patients. The statistical approa...Continue Reading

References

Jan 1, 1986·Clinical and Experimental Dermatology·D S Jolliffe
Jun 6, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·G LippiG Guidi
Jun 17, 1998·The Journal of Clinical Endocrinology and Metabolism·F R SingerP J Bekker
Dec 17, 2004·Journal of Clinical Pharmacology·Robert L WalskyR Scott Obach
Oct 26, 2005·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Robert E MarxVishtasb Broumand
May 17, 2006·Annals of Internal Medicine·Sook-Bin WooJohn R Kalmar
Mar 4, 2008·Bone·René RizzoliJean-Yves Reginster
Jun 19, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ana O HoffGabriel N Hortobagyi
Mar 19, 2009·Clinical Oral Investigations·C WalterT Ziebart
May 6, 2009·Oral Diseases·M E SarasqueteR García-Sanz
May 29, 2010·Journal of Cancer Research and Clinical Oncology·O FilleulS Saussez
Oct 26, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Sven OttoMatthias Schieker
Dec 24, 2010·British Journal of Clinical Pharmacology·Landry K KamdemZeruesenay Desta

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Citations

Feb 27, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Brett M ClarkeBrendan C Stack
Jan 2, 2016·Pharmacological Reviews·Janne T BackmanPertti J Neuvonen
Aug 25, 2015·Oral and Maxillofacial Surgery Clinics of North America·P L FungS Fedele
Dec 22, 2017·Clinical Implant Dentistry and Related Research·Ki-Yeol KimIn-Ho Cha
Jul 23, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Noam YaromDeborah P Saunders
Sep 1, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Guang YangYan Gong
Aug 20, 2019·Journal of the National Cancer Institute. Monographs·Cesar A MiglioratiDouglas E Peterson

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