PMID: 4425917Nov 23, 1974Paper

New approach to assessment of cardioselectivity of beta-blocking drugs

British Medical Journal
C R KumanaD M Smith

Abstract

Propranolol, practolol, and placebo were each given intravenously at weekly intervals to six normal subjects, and their effects on respiratory function tests and heart rates assessed. The reduction in the exercise heart rate after each of the two drugs was most comparable at six hours, indicating a similar degree of cardiac beta-blockade, when the plasma concentration ratio of practolol to propranolol was 28:1. The peak flow rate (PFR) was higher at all times during exercise than at rest. There were significant differences between the changes in resting and exercise PFR after placebo and the reductions after propranolol (except at 24 hours), but not after practolol-and the latter's influence on PFR seemed to be intermediate to that of propranolol and placebo. At six hours, when the cardiac beta-blocking activity of the two drugs was almost the same, there was a significant difference (P 0.025) between the reductions in exercise PFR associated with each drug.

References

Apr 1, 1973·The Journal of Clinical Investigation·G BodemC A Chidsey
Apr 21, 1973·British Medical Journal·S G CarruthersM J Walsh
Jul 26, 1974·European Journal of Clinical Pharmacology·C R Kumana, C M Kaye
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Citations

Jan 1, 1984·European Journal of Clinical Pharmacology·J S Gill, D G Beevers
Jan 1, 1985·European Journal of Clinical Pharmacology·M MauryJ F Giudicelli
Jan 1, 1984·European Journal of Clinical Pharmacology·H W ClagueS G Carruthers
Jan 1, 1977·European Journal of Clinical Pharmacology·N P Boye, J R Vale
Mar 17, 1978·European Journal of Clinical Pharmacology·C C ChristensenG Hansen
Mar 26, 1979·European Journal of Clinical Pharmacology·V M OhP Turner
Jan 1, 1985·European Journal of Clinical Pharmacology·C ThuillezJ F Giudicelli
May 21, 1979·European Journal of Clinical Pharmacology·K L WoodsR J Grieve
Jan 1, 1990·Pharmacology & Therapeutics·T H Pringle, J G Riddell
Apr 1, 1975·British Journal of Clinical Pharmacology·G E MarlinP Turner
Feb 1, 1977·British Journal of Clinical Pharmacology·D A RichardsJ G Maconochie
Apr 1, 1977·British Journal of Clinical Pharmacology·J F GiudicelliA Berdeaux
Apr 1, 1977·British Journal of Clinical Pharmacology·J G MaconochieD A Richards
Aug 1, 1977·British Journal of Clinical Pharmacology·D G McDevitt
Aug 1, 1978·British Journal of Clinical Pharmacology·V M OhJ Wadsworth
Mar 1, 1978·British Journal of Clinical Pharmacology·N Berend, G E Marlin
Jun 1, 1978·British Journal of Clinical Pharmacology·C R Kumana, R Ruffin
Jun 1, 1979·British Journal of Clinical Pharmacology·H R GribbinA E Tattersfield
Jul 1, 1979·British Journal of Pharmacology·J Maclagan, U M Ney
May 15, 1987·The American Journal of Cardiology·B N Prichard
Jul 1, 1980·British Journal of Clinical Pharmacology·J F GiudicelliP L Morselli
Jul 19, 1975·Lancet·C R KumanaJ Hamer
Jan 1, 1988·Fundamental & Clinical Pharmacology·A BerdeauxJ F Giudicelli
Feb 1, 1978·British Journal of Clinical Pharmacology·D G McDevitt
Aug 1, 1978·British Journal of Clinical Pharmacology·C R Kumana
Jan 1, 1976·Acta Medica Scandinavica·J Schaanning, J S Vilsvik
Dec 1, 1983·British Journal of Clinical Pharmacology·W M EdmondstoneD M Denison
Apr 1, 1979·British Journal of Clinical Pharmacology·B N Prichard, D A Richards

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