New approaches for antirheumatic therapy

Baillière's Clinical Rheumatology
B Kirkham, G S Panayi

Abstract

New approaches for antirheumatic therapy are firmly based on current knowledge of immunopathogenic processes. Specific immunotherapy is directed at the treatment of the disease per se and not the production of generalized immunosuppression with its unwanted side-effects. The three targets against which specific immunotherapy is directed are the T cell receptor, the HLA antigen linked to the disease and the antigenic peptide involved in the initiation and/or persistence of the disease. Therapies directed against lymphokines, monokines and cytokines produced during the chronic immune-mediated inflammation are also being developed but they may be unsuccessful not only because of the great redundancy inbuilt into the inflammatory response but also because they would produce too general a response with possibilities of harmful side-effects. Specific immunotherapy at present is largely through the use of monoclonal antibodies directed against a variety of T cell membrane antigens such as CD4, CD7 and the interleukin 2 receptor. A possible therapy is monoclonal antibodies, directed against the HLA molecule involved in the aetiopathogenesis of disease. The use of disease-causing T cell lines or clones as vaccines or therapeutic agents ...Continue Reading

References

Jan 1, 1990·Agents and Actions·M E BillinghamS Carney
Jan 1, 1989·Annual Review of Immunology·H Waldmann
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B P WordsworthJ I Bell
Jun 30, 1989·Cell·R H Schwartz
Dec 1, 1989·The Journal of Experimental Medicine·M BrüggemannM S Neuberger
Nov 2, 1989·Nature·J D Rodwell
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A F LoBuglioM B Khazaeli
Apr 3, 1986·Nature·R J Benjamin, H Waldmann
Sep 1, 1987·The Journal of Experimental Medicine·C O JacobH O McDevitt
Jan 1, 1987·Annals of Internal Medicine·E P BalabanE P Frenkel
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C BoitardH O McDevitt
Sep 1, 1985·The Journal of Experimental Medicine·G E RangesS M Cooper
Oct 1, 1983·The Journal of Experimental Medicine·S Sriram, L Steinman
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M K WaldorL Steinman
Oct 1, 1983·The Journal of Experimental Medicine·N E AdelmanH O McDevitt
Apr 1, 1985·Immunology Today·G Trinchieri, B Perussia

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Citations

Jun 1, 1992·Baillière's Clinical Rheumatology·J M Dayer, H Fenner
Apr 1, 1993·Australian and New Zealand Journal of Medicine·P M Brooks

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