PMID: 6987927Jan 1, 1980Paper

New approaches for immunosuppression

The American Surgeon
B EisemanR Weil

Abstract

New approaches for experimental immunosuppression have been reviewed. These include the following: 1) cyclosporin A, a metabolite from fungus that suppresses multiplying but not resting T and B lymphocytes and can be used in pulsed manner with interspersed drug-free periods; 2) total lymphoid irradiation (transplantation tolerance in rats has been achieved by pretransplant radiation); 3) thoracic duct drainage, which is being revived following its demonstrated effectiveness in the treatment of some autoimmune disease; 4) hyperbaric oxygen (HBOX). We have found that HBOX 2 1/2 ATA for five hours daily depresses cell-mediated immunity in mice and that this can be reversed by intravenous administration of autologous macrophages.

Related Concepts

Cyclosporins
Drainage Procedure
Hyperbaric Oxygenation Therapy
Cellular Immune Response
Therapeutic Immunosuppression
Immunosuppressive Agents
Cyclic Peptides
Thoracic Duct
Transplantation, Homologous
Kidney Transplantation

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