New approaches targeting brown adipose tissue transplantation as a therapy in obesity

Biochemical Pharmacology
M Carmen Soler-VázquezLaura Herrero

Abstract

Brown adipose tissue (BAT) is raising high expectations as a potential target in the fight against metabolic disorders such as obesity and type 2 diabetes. BAT utilizes fuels such as fatty acids to maintain body temperature by uncoupling mitochondrial electron transport to produce heat instead of ATP. This process is called thermogenesis. BAT was considered to be exclusive to rodents and human neonates. However, in the last decade several studies have demonstrated that BAT is not only present but also active in adult humans and that its activity is reduced in several pathological conditions, such as aging, obesity, and diabetes. Thus, tremendous efforts are being made by the scientific community to enhance either BAT mass or activity. Several activators of thermogenesis have been described, such as natriuretic peptides, bone morphogenic proteins, or fibroblast growth factor 21. Furthermore, recent studies have tested a therapeutic approach to directly increase BAT mass by the implantation of either adipocytes or fat tissue. This approach might have an important future in regenerative medicine and in the fight against metabolic disorders. Here, we review the emerging field of BAT transplantation including the various sources of ...Continue Reading

Citations

Feb 13, 2019·Frontiers in Physiology·Seung-Hyun RoZachery D Shomo
Feb 6, 2020·Cells·Marianela Bastías-PérezLaura Herrero
Oct 28, 2019·Scientific Reports·Chen GilorOuliana Ziouzenkova
Jun 6, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Moloud PayabBabak Arjmand
Feb 20, 2019·Stem Cells Translational Medicine·Tao LvRan Xiao
Jan 12, 2021·Frontiers in Endocrinology·Ya-Nan DuanJing-Ya Li
Apr 17, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T C PeixotoP C Lisboa
Mar 2, 2019·European Journal of Pharmacology·Kripa ShankarAnil Nilkanth Gaikwad
Dec 24, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Junrong CaiFeng Lu

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