New approaches to anti-inflammatory therapy for asthma

The American Journal of Medicine
S E Wenzel

Abstract

Currently, corticosteroids are the therapy of choice for the inflammatory component of asthma. This class of drug provides powerful anti-inflammatory effects in most patients; however, these effects are not specific and in some cases may result in serious side effects. Also, many patients have difficulty adhering to therapy with inhaled forms of these drugs, which are administered by metered-dose inhalers up to several times per day. There are several other therapies that provide potential anti-inflammatory effects, but they are of low efficacy, with little definitive anti-inflammatory effect. While efforts are currently under way to improve corticosteroid therapy, other directions include the development of targeted anti-inflammatory agents. For example, the leukotrienes, a family of inflammatory mediators that have been shown to enhance bronchoconstriction and airway mucus secretion, have been the focus of numerous investigations. Specific leukotriene receptor antagonists and synthesis inhibitors have been developed and are currently showing promise in clinical trials; one leukotriene receptor antagonist (zafirlukast) and one 5-lipoxygenase inhibitor (zileuton) were recently approved by the United States Food and Drug Adminis...Continue Reading

References

Mar 1, 1992·The American Review of Respiratory Disease·R DjukanovićS T Holgate
Aug 1, 1991·The Journal of Allergy and Clinical Immunology·P D DyerR W Weber
Oct 1, 1991·The American Review of Respiratory Disease·P E ChristieT H Lee
Nov 1, 1995·The Journal of Allergy and Clinical Immunology·N A HananiaS Kesten
Aug 1, 1995·Allergy·R A PauwelsJ C Kips
Apr 7, 1995·The Journal of Biological Chemistry·J M SametF H Chilton
Nov 1, 1995·American Journal of Respiratory and Critical Care Medicine·M NoonanD Kellerman
Jul 1, 1995·American Journal of Respiratory and Critical Care Medicine·H BoothE H Walters
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine·S E WenzelJ Y Westcott
Jun 1, 1995·The Journal of Allergy and Clinical Immunology·D J PincusR J Martin
Jun 27, 1994·Archives of Internal Medicine·J S KellowayS A Adlis
Jul 1, 1994·American Journal of Respiratory and Critical Care Medicine·M DecramerP Rogiers
Sep 15, 1994·The New England Journal of Medicine·T HaahtelaA Sovijärvi
Sep 1, 1994·The Journal of Allergy and Clinical Immunology·G E StewartD K Ledford
Apr 1, 1994·American Journal of Respiratory and Critical Care Medicine·R DworskiJ R Sheller
May 1, 1994·American Journal of Respiratory and Critical Care Medicine·E MelilloP M O'Byrne
Dec 1, 1993·Annals of Internal Medicine·E IsraelJ M Drazen
Dec 1, 1993·The American Review of Respiratory Disease·E IsraelJ M Drazen
Sep 1, 1993·The Journal of Allergy and Clinical Immunology·D Cypcar, W W Busse
Apr 1, 1993·The American Review of Respiratory Disease·B S FriedmanP Sterk
Jul 1, 1993·The Journal of Allergy and Clinical Immunology·Z Pelikan, I Knottnerus
Jan 1, 1993·International Archives of Allergy and Immunology·J J TsaiS R Wang
Feb 1, 1996·American Journal of Respiratory and Critical Care Medicine·S H LockN C Barnes
Feb 1, 1996·American Journal of Respiratory and Critical Care Medicine·A SzczeklikA Cmiel
Feb 1, 1996·American Journal of Respiratory and Critical Care Medicine·P SestiniM Robuschi
Jan 1, 1996·The Journal of Allergy and Clinical Immunology·M Johnson

❮ Previous
Next ❯

Citations

Jun 1, 2000·Indian Journal of Pediatrics·G Gupta
Apr 23, 2002·The British Journal of Dermatology·Kathleen J SmithH Skelton
Oct 30, 2003·The Cochrane Database of Systematic Reviews·A DeweyE H Walters
Sep 2, 2006·Obstetrics and Gynecology·Mitchell P Dombrowski
Jun 6, 2002·Clinical Obstetrics and Gynecology·Cornelia R Graves
Mar 10, 2001·British Journal of Nursing : BJN·A L Coakley
Mar 5, 1999·Biochimica Et Biophysica Acta·M Liminga, E Oliw
Jul 25, 2003·Pulmonary Pharmacology & Therapeutics·Gaetano Caramori, Ian Adcock

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

© 2022 Meta ULC. All rights reserved