PMID: 3756811Oct 15, 1986Paper

New approaches to the possible prevention of side effects of chemotherapy by nutrition

Cancer
J PintoR S Rivlin

Abstract

In an effort to develop new methods for preventing side effects of chemotherapy, the authors initiated studies to determine whether Adriamycin (doxorubicin) inhibits the metabolism of riboflavin (vitamin B2). Adriamycin has been shown to form a 1:1 stoichiometric complex with riboflavin, as well as to compete for binding to tissue proteins. Adult rats treated with Adriamycin in clinically relevant doses were compared to control animals in ability to convert riboflavin into flavin adenine dinucleotide (FAD), the active flavin coenzyme derivative, in heart, skeletal muscle, liver, and kidney. Rats treated with Adriamycin exhibited diminished formation of carbon 14 (14C)FAD in skeletal muscle to nearly 50% that of controls, and in heart to about 70% to 80% of controls. Under these conditions, (14C)FAD formation in liver and kidney was largely unaffected by Adriamycin. In preliminary studies, riboflavin-deficient animals treated with Adriamycin had accelerated mortality rates compared to those of food restricted controls treated with similar doses of Adriamycin. The data as a whole suggest a potential mechanism for Adriamycin-induced cardiac and skeletal myopathy, i.e., inhibition of synthesis of FAD, a flavin coenzyme which is inv...Continue Reading

References

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Citations

Jan 1, 1992·Free Radical Biology & Medicine·M Sugiyama
Dec 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J Ning, M H Grant
Jul 11, 2008·Journal of Applied Toxicology : JAT·Subhendra N MattagajasinghHara P Misra
Mar 31, 1989·Biochemical and Biophysical Research Communications·M SugiyamaR Ogura
Jan 26, 2005·Basic & Clinical Pharmacology & Toxicology·Suvara K WattanapitayakulJohn A Bauer

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