New approaches to treating pain

Bioorganic & Medicinal Chemistry Letters
Andrea WolkerstorferHelmut Buschmann

Abstract

Pain is the most common reason for patients seeking medical care resulting in an estimated world market for analgesics of more than USD 50 billion. Pain is a highly complex, heterogeneous and dynamic process characterized by specific patterns of phenotypic sensory neuronal change. Current treatment options for pain include opioids and non-opioid analgesics, acetaminophen and non-steroidal anti-inflammatory drugs and other drug classes such as antidepressants and anticonvulsants and a combination thereof. Novel approaches are focusing on the optimization of side-effect profiles of opioid based analgesics, the improvement of selectivity for specific opioid receptors, or by addressing molecular gateways implicated in pain. Promising candidates in development target various types of voltage-gated ion channels and receptors for capsaicin and analogs. Currently, after decades of pain research it has to be stated that the assessment, prevention and treatment of pain in industrialized countries as well as in low-income and middle-income countries are neither adequate nor equitable. Further research is needed so that specifically chronic pain control can be improved and individualized.

References

Jul 22, 1998·European Journal of Pharmacology·W Reimann, F Schneider
Oct 18, 2003·Histochemistry and Cell Biology·Huai Zhen Ruan, Geoffrey Burnstock
Mar 3, 2004·Drug News & Perspectives·Peter A Smith
Jun 29, 2004·Muscle & Nerve·Gil I Wolfe, Jaya R Trivedi
Oct 29, 2004·Clinical Pharmacokinetics·Stefan Grond, Armin Sablotzki
Dec 16, 2006·CNS & Neurological Disorders Drug Targets·Slobodan M Todorovic, Vesna Jevtovic-Todorovic
Feb 3, 2007·Current Drug Targets·L-C ChiouE P Prinssen
Apr 28, 2007·Nature Reviews. Drug Discovery·Arpad SzallasiSamer R Eid
Oct 30, 2007·Pharmacotherapy·Michael W Jann, Julian H Slade
Jan 16, 2008·CNS Drugs·Gary McCleane
Jan 23, 2008·The Clinical Journal of Pain·Helena KnotkovaArpad Szallasi
Aug 2, 2008·Nature Reviews. Drug Discovery·David G Lambert
Jan 20, 2009·Brain Research Reviews·Praveen AnandAndrea G Hohmann
Feb 3, 2009·The AAPS Journal·Joel E SchlosburgAron H Lichtman
Jan 20, 2010·The Clinical Journal of Pain·Todd W Vanderah
Jan 30, 2010·Clinical Therapeutics·William E Wade, William J Spruill
Mar 27, 2010·The Journal of Pain : Official Journal of the American Pain Society·Robert B RaffaRonald J Tallarida
Jul 24, 2010·Nature Reviews. Drug Discovery·Irena Melnikova
Nov 4, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Susan CollinsRoberto S G M Perez
May 6, 2011·CA: a Cancer Journal for Clinicians·Judith A Paice, Betty Ferrell
Jun 28, 2011·Lancet·Christopher L Wu, Srinivasa N Raja
Jun 28, 2011·Lancet·Dennis C TurkAlex Cahana
Jun 28, 2011·Lancet·Russell K Portenoy
Sep 20, 2011·Trends in Pharmacological Sciences·Amynah A PradhanBrigitte L Kieffer
Feb 2, 2012·Nature Reviews. Drug Discovery·Sarah Nightingale
Apr 3, 2012·Drug Discovery Today·Iain P ChessellAndy Billinton
Jun 16, 2012·Expert Opinion on Pharmacotherapy·Robert B RaffaThomas M Tzschentke
Sep 5, 2012·ChemMedChem·Antonio NardiAchim Kless
Mar 19, 2013·European Journal of Pharmacology·Jill-Desiree BredersonArpad Szallasi
Mar 19, 2013·European Journal of Pharmacology·Katarzyna Starowicz, Vincenzo Di Marzo
Mar 19, 2013·European Journal of Pharmacology·Daniel ZamanilloJosé Miguel Vela
Jun 5, 2013·Toxicon : Official Journal of the International Society on Toxinology·Jia-Wei MinBi-Wen Peng
Aug 27, 2013·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Alisia A MitchellMichael Stanton-Hicks
Jan 28, 2014·Trends in Neurosciences·Christoforos Tsantoulas, Stephen B McMahon
Jun 1, 2014·Trends in Pharmacological Sciences·Jonathan D ViolinMichael W Lark
Jul 22, 2014·Nature·Arun K ShuklaRobert J Lefkowitz
Aug 1, 2014·Future Medicinal Chemistry·Carmen Almansa, José Miguel Vela
Sep 15, 2014·Drug Discovery Today·Michael S Kinch
Mar 3, 2015·Journal of Clinical Pharmacy and Therapeutics·J F Peppin, R B Raffa

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Citations

Jun 12, 2017·British Journal of Pharmacology·Adrianne R Wilson-Poe, Jose A Morón
Jul 21, 2017·Pain Management·Hélène BeaudryPhilippe Séguéla
Sep 6, 2017·Scientific Reports·Laurie-Anne RoeckelClaire Gaveriaux-Ruff
Jul 7, 2016·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hyun ParkDawon Kang
Nov 14, 2017·Skin Pharmacology and Physiology·Iga Hołyńska-IwanDorota Olszewska-Słonina
May 17, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guilherme Carneiro MontesGisele Zapata-Sudo
Jun 1, 2016·ChemMedChem·Francesca AielloAntonella Brizzi
Jul 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Victor FattoriWaldiceu A Verri
Jun 27, 2019·Medicinal Chemistry·Nehaben A GujaratiVijaya L Korlipara
Dec 22, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ho-Sung LeeDae-Yeon Lee
Mar 10, 2020·Neuroscience and Biobehavioral Reviews·Rafael González-CanoEnrique J Cobos

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