New aspects in systemic treatment of atopic dermatitis

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
Thomas WerfelAnnice Heratizadeh

Abstract

In severe cases of atopic dermatitis (AD) systemic treatment is indicated. So far, cyclosporine and systemic glucocorticosteroids represented the only systemic treatment options approved for the indications of AD in Germany; however, from clinical practice there is increasing evidence for beneficial therapeutic effects in AD by other immunosuppressive or immunomodulatory substances, such as mycophenolate, methotrexate, alitretinoin and ustekinumab. Beyond this, ongoing research activities focus on a better understanding of genetic and immunological aspects of this chronic inflammatory skin disease. Regarding treatment with mycophenolate, genetic polymorphisms in AD patients could be identified that might predict responsiveness to this medication. Moreover, several new substances specifically targeting inflammation in AD are currently being studied and the first promising treatment effects on skin condition and pruritic symptoms of AD could be observed. As an exceptional result of this development in September 2017 in Europe and therefore in Germany the first biologic as first-line treatment was approved for the indication of moderate to severe AD in adults. Dupilumab is a human monoclonal IgG4 antibody that blocks a subunit of ...Continue Reading

References

Nov 6, 2009·The British Journal of Dermatology·M GrahovacA Wollenberg
Dec 20, 2011·The Journal of Allergy and Clinical Immunology·Christian CornelissenJens M Baron
Dec 21, 2011·International Journal of Dermatology·Rafael PuyaJosé Carlos Moreno
Jul 19, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·J RingUNKNOWN Global Allergy and Asthma European Network (GA2LEN)
Jul 21, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·J RingUNKNOWN Global Allergy and Asthma European Network
Aug 11, 2012·Annals of Dermatology·Andreas Wollenberg, Laura Maximiliane Ehmann
Jun 20, 2013·The Journal of Allergy and Clinical Immunology·Mayte Suárez-FariñasEmma Guttman-Yassky
Sep 5, 2013·Annals of Dermatology·Anna Agusti-MejiasIsabel Febrer
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Peter D ArkwrightUNKNOWN Atopic Dermatitis Working Group of the Allergic Skin Diseases Committee of the AAAAI
Feb 17, 2015·The British Journal of Dermatology·J van der SchaftM S de Bruin-Weller
Dec 30, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Thomas WerfelMargitta Worm
Dec 30, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Thomas WerfelUNKNOWN Association of Scientific Medical Societies of Germany
Mar 24, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·A WollenbergUNKNOWN European Task Force on Atopic Dermatitis/EADV Eczema Task Force
Apr 16, 2016·Clinical and Experimental Dermatology·C WlodekC T Kennedy
Jun 16, 2016·Experimental Dermatology·Saakshi KhattriEmma Guttman-Yassky
Aug 24, 2016·The Journal of Dermatological Treatment·J L ThijsM S De Bruin-Weller
Oct 4, 2016·The New England Journal of Medicine·Eric L SimpsonUNKNOWN SOLO 1 and SOLO 2 Investigators
Oct 14, 2016·Allergy·A Heratizadeh, T Werfel
Oct 18, 2016·Journal of the American Academy of Dermatology·Doris WeissChristine Bangert
Dec 23, 2016·The British Journal of Dermatology·E Nic DhonnchaL Paul
Feb 1, 2017·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jochen SchmittThomas Werfel
Mar 1, 2017·The Journal of Allergy and Clinical Immunology·Annice HeratizadehUNKNOWN Arbeitsgemeinschaft Neurodermitisschulung für Erwachsene (ARNE) Study Group
Mar 2, 2017·The New England Journal of Medicine·Thomas RuzickaUNKNOWN XCIMA Study Group
Jul 15, 2017·Cell·Howard Y Chang, Kari C Nadeau
Jul 22, 2017·Pediatric Dermatology·Veronika DvorakovaAlan D Irvine
Aug 15, 2017·Journal of the American Academy of Dermatology·Eric L SimpsonAmy S Paller
Sep 10, 2017·The Journal of Allergy and Clinical Immunology·Amy S PallerThomas Bieber
Nov 22, 2017·MMW Fortschritte der Medizin·Andreas WollenbergBeate Hagl

❮ Previous
Next ❯

Citations

Feb 28, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A Wollenberg, T Biedermann
Sep 20, 2019·Der Orthopäde·S StänderD Thaçi
Apr 20, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·J RingA Fink-Wagner
Dec 6, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·W PfütznerC Möbs
Nov 18, 2020·The Journal of Dermatological Treatment·Husein Husein-ElAhmed, Martin Steinhoff

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.

Related Papers

The Medical Journal of Australia
Victoria R Harris, Alan J Cooper
The Journal of Allergy and Clinical Immunology. in Practice
Mark Boguniewicz
© 2022 Meta ULC. All rights reserved