New Aspects of Lipotoxicity in Nonalcoholic Steatohepatitis

International Journal of Molecular Sciences
Nahum Mendez-SanchezJaqueline Cordova-Gallardo

Abstract

NASH is becoming increasingly common worldwide because of the growing global prevalence of obesity and consequently NAFLD. Unfortunately, the mechanism of progression of NAFLD to NASH and then cirrhosis is not completely understood. Several factors, including insulin resistance, inflammation, oxidative stress, lipotoxicity, and bile acid (BA) toxicity, have been reported to be associated with NASH progression. The release of fatty acids from dysfunctional and insulin-resistant adipocytes results in lipotoxicity, which is caused by the ectopic accumulation of triglyceride-derived toxic metabolites and the subsequent activation of inflammatory pathways, cellular dysfunction, and lipoapoptosis. Adipose tissue (AT), especially visceral AT, comprises multiple cell populations that produce adipokines and insulin-like growth factor, plus macrophages and other immune cells that stimulate the development of lipotoxic liver disease. These biomolecules have been recently linked with many digestive diseases and gastrointestinal malignancies such as hepatocellular carcinoma. This made us question what role lipotoxicity has in the natural history of liver fibrosis. Therefore, this review focuses on the close relationship between AT and NASH....Continue Reading

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Citations

Mar 25, 2019·Expert Review of Gastroenterology & Hepatology·Carlos Esteban Coronel-CastilloNahum Méndez-Sánchez
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Apr 3, 2021·Autophagy·Yasmina Filali-MouncefFulvio Reggiori
Apr 10, 2021·Frontiers in Immunology·Nahum Méndez-SánchezMohammed Eslam
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Nov 2, 2021·Visceral Medicine·Nela Melissa Parra-LandazuryNahum Méndez-Sánchez

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Methods Mentioned

BETA
reacylation

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