New aspects of nuclear calcium signalling

Journal of Cell Science
O V Gerasimenko, J V Gerasimenko

Abstract

Nuclear calcium signalling has been a controversial battlefield for many years and the question of how permeable the nuclear pore complexes (NPCs) are to Ca2+ has been the subject of a particularly hot dispute. Recent data from isolated nuclei suggest that the NPCs are open even after depletion of the Ca2+ store in the nuclear envelope. Other research has suggested that a new Ca2+ -releasing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP), can liberate Ca2+ only from acidic organelles, probably lysosomes, rather than from the traditional Ca2+ store in the endoplasmic reticulum (ER). Recent work indicates that NAADP can release Ca2+ from the nuclear envelope (NE), which has a thapsigargin-sensitive, ER-type Ca2+ store. NAADP acts in a manner similar to inositol (1,4,5)-trisphosphate [Ins(1,4,5)P3] or cyclic ADP-ribose (cADPR): all three messengers are equally able to reduce the Ca2+ concentration inside the NE and this is associated with a transient rise in the nucleoplasmic Ca2+ concentration. The NE contains ryanodine receptors (RyRs) and Ins(1,4,5)P3 receptors [Ins(1,4,5)P3Rs], and these can be activated separately and independently: the RyRs by either NAADP or cADPR, and the Ins(1,4,5)P3Rs by Ins(1,4,5)P3.

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A N MalviyaG Vincendon
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P NicoteraP O Berggren
May 1, 1984·The Biochemical Journal·M JadotR Wattiaux
May 1, 1994·Trends in Pharmacological Sciences·B E EhrlichI Bezprozvanny
Jul 1, 1994·Cellular Signalling·L CoccoR S Gilmour
Feb 24, 1994·Nature·F A al-MohannaS R Bolsover
Jan 1, 1994·Annual Review of Physiology·O H PetersenH Kasai
Apr 1, 1994·The American Journal of Physiology·M BurnierH R Brunner
May 1, 1996·Pflügers Archiv : European journal of physiology·O V GerasimenkoO H Petersen
Sep 1, 1996·The Journal of Membrane Biology·L Santella
Jul 1, 1996·The Journal of Physiology·H Shirakawa, S Miyazaki
Dec 6, 1996·The Journal of Biological Chemistry·M N BadmintonC M Rembold
Mar 1, 1997·The Journal of Physiology·M BootmanP Lipp
Apr 1, 1997·Trends in Pharmacological Sciences·A A Genazzani, A Galione
Aug 1, 1997·The Biochemical Journal·G R BrownP O Berggren
Sep 23, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C Perez-TerzicD E Clapham
Jan 31, 1998·The EMBO Journal·P LippM D Bootman
Mar 28, 1998·Trends in Biochemical Sciences·J Meldolesi, T Pozzan
May 28, 1998·Cell Calcium·M N BadmintonA K Campbell
May 28, 1998·Cell Calcium·O H PetersenA V Tepikin
May 28, 1998·Cell Calcium·M A LeeL Stehno-Bittel
Jun 30, 1998·Pflügers Archiv : European journal of physiology·P P LuiC Y Lee
Sep 2, 1998·The EMBO Journal·L D Robb-GaspersA P Thomas
Nov 14, 1998·Biochemical and Biophysical Research Communications·L SantellaK Kyozuka
Dec 9, 1998·Current Biology : CB·J V GerasimenkoO V Gerasimenko
Feb 2, 1999·The Journal of General Physiology·C Strübing, D E Clapham

❮ Previous
Next ❯

Citations

Oct 5, 2010·Pflügers Archiv : European journal of physiology·Olena FedorenkoSergey Marchenko
Apr 12, 2008·Purinergic Signalling·John MeshkiSatya P Kunapuli
Dec 21, 2011·Protein & Cell·Congyan PanGuangju Ji
Mar 23, 2005·Current Opinion in Cell Biology·Francesco MichelangeliLaura L Wootton
Feb 6, 2009·ACS Chemical Biology·Michael BannwarthKai Johnsson
Jun 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gusheng WuRobert W Ledeen
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ward CapoenGiles E D Oldroyd
May 14, 2010·The Journal of Biological Chemistry·Artavazd TadevosyanStanley Nattel
Dec 11, 2008·Reproductive Biology and Endocrinology : RB&E·Mauricio Díaz-MuñozVerónica Morales-Tlalpan
Feb 26, 2013·Cell Communication and Signaling : CCS·Rodrigo R ResendeM Fatima Leite
Mar 11, 2008·Journal of Lipid Research·Robert W Ledeen, Gusheng Wu
Oct 19, 2012·Journal of Cell Science·Charitha GalvaCraig Gatto
Jun 6, 2014·Molecular Biology and Evolution·Pawel BurkhardtNicole King
Aug 12, 2006·Canadian Journal of Physiology and Pharmacology·Robert W Ledeen, Gusheng Wu
Aug 12, 2006·Canadian Journal of Physiology and Pharmacology·Rebecca K Y LeeS K Kong
Nov 13, 2015·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Raimond L WinslowJoseph L Greenstein
Dec 17, 2014·Biochimica Et Biophysica Acta·Tamara VervloessemJan B Parys
Jan 26, 2016·Biochimica Et Biophysica Acta·Andreas H Guse, Insa M A Wolf
Aug 7, 2012·Neuropeptides·János Tamás PadraGyörgy Paragh
Dec 31, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Khairat ElBaradieZvi Schwartz
Jun 21, 2011·Biochimie·Christian MazarsPatrice Thuleau
Dec 15, 2010·Cell Calcium·Maria Teresa Alonso, Javier García-Sancho
Sep 1, 2007·The Journal of Physiology·Aleksey V ZimaLothar A Blatter
Jan 19, 2008·Cell Calcium·Silvia GuatimosimM Fatima Leite
Dec 21, 2007·Frontiers in Neuroendocrinology·C D ForadoriR J Handa
Mar 13, 2016·Biochimica Et Biophysica Acta·Vanessa ChecchettoIldiko Szabo
Oct 28, 2006·Cell Calcium·María Teresa AlonsoJavier García-Sancho
Jan 13, 2006·Journal of Cellular Biochemistry·Robert W Ledeen, Gusheng Wu
Apr 21, 2007·Annals of the New York Academy of Sciences·Robert W Ledeen, Gusheng Wu
Jan 9, 2009·The New Phytologist·Christian MazarsRaoul Ranjeva
Dec 23, 2011·Biology of the Cell·Jean-Pierre Mauger
Aug 15, 2009·Journal of Neuroscience Research·D L GruolT E Nelson
Sep 12, 2006·Journal of Molecular Biology·Sara M PaulilloBirthe Fahrenkrog
Jun 20, 2006·Biochimica Et Biophysica Acta·John D York
Jul 4, 2006·Biochimica Et Biophysica Acta·Robert W Ledeen, Gusheng Wu
Apr 26, 2006·Neuroscience Letters·Zena De MarchFrancesca R Fusco

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.