New aspects of Saccharomyces cerevisiae as a novel carrier for berberine

Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Roshanak SalariZahra Khashyarmanesh

Abstract

Berberine was encapsulated in yeast cells of Saccharomyces cerevisiae as novel carriers to be used in different food and drug industries. The microcapsules were characterized by differential scanning calorimetry (DSC), fourier transform infra red spectroscopy (FT-IR) and fluorescence microscopy. The encapsulation factors such as plasmolysis of yeast cells which affects the % encapsulation yield were studied. Fluorescence microscopy showed the yeast cells became fluorescent after encapsulation process. DSC diagram was representing of new peak for microcapsule which was not the same as berberine and the empty yeast cells peaks, separately. FTIR spectrums of microcapsules and yeast cells were almost the same. The plasmolysed and non plasmolysed microcapsules were loaded with berberine up to about 40.2 ± 0.2% w/w. Analytical methods proved that berberine was encapsulated in the yeast cells. Fluorescence microscopy and FTIR results showed the entrance of berberine inside the yeasts. DSC diagram indicated the appearance of new peak which is due to the synthesis of new product. Although plasmolysis caused changes in yeast cell structure and properties, it did not enhance berberine loading in the cells. The results confirmed that Sacch...Continue Reading

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Citations

Nov 23, 2018·Expert Opinion on Drug Delivery·Chinnu SabuKannissery Pramod
Oct 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mohammed J Al-AwadyVesselin N Paunov
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giulia Coradello, Nicola Tirelli

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Methods Mentioned

BETA
fluorescence
Infrared Spectroscopy
differential scanning calorimetry

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