New aspects on lanosterol 14alpha-demethylase and cytochrome P450 evolution: lanosterol/cycloartenol diversification and lateral transfer

Journal of Molecular Evolution
Tadeja RezenDamjana Rozman

Abstract

Sterol 14alpha-demethylase (CYP51) is a member of the cytochrome P450 superfamily, widely found in animals, fungi, and plants but present in few prokaryotic groups. CYP51 is currently believed to be the ancestral cytochrome P450 that has been transferred from prokaryotes to eukaryotic kingdoms. We propose an alternate view of CYP51 evolution that has an impact on understanding the evolution of the entire CYP superfamily. Two hundred forty-nine bacterial and four archaeal CYP sequences have been aligned and a bacterial CYP tree designed, showing a separation of two branches. Prokaryotic CYP51s cluster to the minor branch, together with other eukaryote-like CYPs. Mycobacterial and methylococcal CYP51s cluster together (100% bootstrap probability), while Streptomyces CYP51 remains on a distant branch. A CYP51 phylogenetic tree has been constructed from 44 sequences resulting in a ((plant, bacteria),(animal, fungi)) topology (100% bootstrap probability). This is in accordance with the lanosterol/cycloartenol diversification of sterol biosynthesis. The lanosterol branch (nonphotosynthetic lineage) follows the previously proposed topology of animal and fungal orthologues (100% bootstrap probability), while plant and D. discoideum CYP...Continue Reading

References

Nov 1, 1979·CRC Critical Reviews in Biochemistry·K E Bloch
Oct 11, 1993·FEBS Letters·K N Degtyarenko, A I Archakov
Feb 11, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·D R Nelson
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·A BellamineM R Waterman
Aug 27, 1999·Archives of Biochemistry and Biophysics·D R Nelson
Dec 10, 1999·Molecular and Biochemical Parasitology·A LiendoJ A Urbina
Jun 1, 2000·Nature·H OchmanE A Groisman
Sep 6, 2000·Molecular Microbiology·Y Boucher, W F Doolittle
Sep 12, 2001·Molecular and Biochemical Parasitology·B M JoubertF S Buckner
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W D NesE R Katz
Dec 26, 2001·Trends in Genetics : TIG·Junaid GamieldienWinston Hide
Feb 12, 2002·International Journal of Systematic and Evolutionary Microbiology·T Cavalier-Smith
Apr 12, 2002·The Journal of Biological Chemistry·David C LambSteven L Kelly
Nov 26, 2002·Molecular Biology and Evolution·J Peter GogartenJeffrey G Lawrence
Dec 5, 2002·Archives of Biochemistry and Biophysics·Natasa DebeljakDamjana Rozman
Jan 22, 2003·Applied Microbiology and Biotechnology·J K Volkman
Feb 5, 2003·Biochemical and Biophysical Research Communications·Colin J JacksonSteven L Kelly

❮ Previous
Next ❯

Citations

Jun 7, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Roger E SummonsJacob R Waldbauer
Jan 9, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Hideki SezutsuRené Feyereisen
Jan 9, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David R NelsonJohn J Stegeman
Oct 25, 2012·Journal of Lipid Research·Rok KeberSimon Horvat
Dec 3, 2014·Journal of Environmental Sciences (China)·Muhil Vannan SeralathanTapan Chakrabarti
Jul 26, 2006·Expert Opinion on Drug Metabolism & Toxicology·David C LambMichael R Waterman
Sep 16, 2008·Mutation Research·Aleksandra FucicTomislav Dobranic
Apr 4, 2006·Trends in Microbiology·Kirsty J McLeanAndrew W Munro
Jan 14, 2010·Journal of Biochemistry·Tsuneo Omura
Sep 12, 2006·Biochimica Et Biophysica Acta·Galina I Lepesheva, Michael R Waterman
Nov 25, 2017·Frontiers in Plant Science·Sumit Ghosh
Apr 17, 2013·Biotechnology and Applied Biochemistry·Tsuneo Omura
Feb 4, 2012·The Arabidopsis Book·Søren BakDanièle Werck-Reichhart
Dec 7, 2018·Ecology and Evolution·Ping Feng, Zhijun Liu
Feb 25, 2017·Frontiers in Immunology·Harry NewmarkPeter Ghazal
May 10, 2019·Frontiers in Microbiology·Jingxiang ZhangYuanying Jiang
Aug 5, 2020·Antioxidants·Marco MiceraGiulia Querio
Oct 9, 2020·Molecular Biology and Evolution·David C LambGalina I Lepesheva
Jul 26, 2018·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Wenxu ZhouW David Nes
Sep 10, 2020·Bioorganic Chemistry·Mohammad ShafieiAlireza Foroumadi
Nov 14, 2006·Biochimica Et Biophysica Acta·Matej Seliskar, Damjana Rozman
Oct 23, 2014·Chemical Reviews·Jun Yong ChoiWilliam R Roush
Jul 2, 2005·The Journal of Organic Chemistry·Quanbo XiongSeiichi P T Matsuda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.