Abstract
Several recent studies suggest that serum anti-p53 antibodies (s-p53-Abs) may be combined with other markers to detect esophageal and colorectal cancer. In this study, we assessed the sensitivity and specificity of s-p53-Abs detection of a new electrochemiluminescence immunoassay (ECLIA; Elecsys anti-p53). Elecsys anti-p53 assay was used to analyze the level of s-p53-Abs in blood sera from patients with esophageal or colorectal cancer taken before treatment. Control blood sera from healthy volunteers, patients with benign diseases, and patients with autoimmune diseases served as a reference. In addition, squamous cell carcinoma antigen (SCC-Ag) and cytokeratin 19 fragments (CYFRA21-1) were assessed in patients with esophageal cancer, and carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 were assessed in patients with colorectal cancer. Samples from 281 patients with esophageal cancer, 232 patients with colorectal cancer, and 532 controls were included in the study. The median value of s-p53-Abs in control samples was < 0.02 μg/mL (range < 0.02-29.2 μg/mL). Assuming 98% specificity, the cut-off value was determined as 0.05 μg/mL. s-p53-Abs were detected in 20% (57/281) of patients with esophageal cancer and 18% (...Continue Reading
References
Jan 28, 2003·Cancer·Hideaki ShimadaUNKNOWN Japan p53 Antibody Research Group
Aug 28, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Norbert WildJohann Karl
Mar 13, 2012·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Takashi HimotoTsutomu Masaki
Aug 8, 2013·World Journal of Gastroenterology : WJG·Aravind Suppiah, John Greenman
Dec 4, 2013·The American Journal of Gastroenterology·Yi-Wei XuLi-Yan Xu
Jan 20, 2015·Critical Reviews in Immunology·Hiroaki TakatoriHiroshi Nakajima
Jan 8, 2017·Surgery Today·Ryuma TokunagaHideo Baba
Jan 22, 2017·World Journal of Surgery·Kotaro YamashitaYuichiro Doki
Sep 1, 2017·Molecular and Clinical Oncology·Kensuke KumamotoKeiichiro Ishibashi
Jul 1, 2018·Esophagus : Official Journal of the Japan Esophageal Society·Takashi SuzukiHideaki Shimada
Jul 14, 2018·Annals of Gastroenterological Surgery·Hideaki Shimada
Sep 19, 2018·Esophagus : Official Journal of the Japan Esophageal Society·Terufumi KawamotoKatsuyuki Karasawa
Nov 15, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yi-Wei XuYu-Hui Peng
Feb 20, 2019·Esophagus : Official Journal of the Japan Esophageal Society·Fumiaki ShiratoriHideaki Shimada
Jun 4, 2019·BMC Cancer·Yuchong YangYi Ba
Dec 11, 2019·International Journal of Clinical Oncology·Mitsunori UshigomeKimihiko Funahashi
Dec 14, 2019·International Journal of Clinical Oncology·Nobuya DaitokuHideo Baba
Citations
Nov 26, 2020·Annals of Surgical Oncology·Hideaki Shimada
Mar 7, 2021·Cancers·Hugo de JongeClaudia Scotti
Aug 3, 2021·Disease Markers·Shi-Han YangYi-Wei Xu