PMID: 9002060Dec 1, 1996Paper

New assessment techniques for evaluation of posttraumatic spinal cord function in the rat

Journal of Neurotrauma
H van de MeentW H Gispen

Abstract

To evaluate new pharmacologic agents with potentially beneficial effects on posttraumatic spinal cord function, we used a modified weight drop (WD) technique to induce spinal cord injuries. These contusive spinal cord injuries in the rat closely mimic the human clinicopathologic situation. Especially for drug screening purposes, the moderate and mild injuries are of interest, as both the beneficial and potentially harmful effects of experimental treatment can be detected. In this study, we describe two new functional tests that were particularly designed to detect small differences in spinal cord function after moderate and mild injuries. First, for examination of locomotion, a computer analysis of the thoracolumbar height (TLH) was designed. Second, for investigation of the conduction properties of the injured rat spinal cord, we measured rubrospinal motor evoked potentials (MEP). The efficacy of the new assessment techniques to monitor spinal cord function was compared to Tarlov scores and to morphometric analysis of preserved white matter at the injury site. The results of this study indicated that for behavioral analysis, TLH measurements as compared with Tarlov rating appeared to be more sensitive for exact and objective d...Continue Reading

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Citations

May 7, 2002·Journal of Neuroscience Research·O NesicJ R Perez-Polo
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Berit E PowersPhilip J Horner
Jun 14, 2003·Journal of Neurotrauma·Guillermo García-AlíasXavier Navarro
Nov 1, 2003·Journal of Neurotrauma·Nico L U Van MeeterenFrank P T Hamers
Apr 25, 2006·Journal of Neurotrauma·Frank P T HamersElbert A J Joosten
Apr 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jurate LasienePhilip Horner
Aug 27, 2004·The Tohoku Journal of Experimental Medicine·Hideki MoriyamaYoshiko Tobimatsu
Nov 27, 2007·Neuroscience and Biobehavioral Reviews·Jirí SedýEva Syková
Aug 19, 2007·Osteoarthritis and Cartilage·H MoriyamaY Tobimatsu
Mar 30, 2010·Journal of Neuroscience Methods·Ming-Wen ChangMao-Tsun Lin
Jun 16, 2019·Spinal Cord·Hideki MoriyamaToshihiro Akisue
May 23, 2017·Calcified Tissue International·Naoyoshi SakitaniHideki Moriyama

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