New automated immunoassay measuring immunoglobulin A antigliadin antibodies for prediction of celiac disease in childhood

Clinical and Diagnostic Laboratory Immunology
E GrodzinskyOlle Hernell

Abstract

The prevalence of celiac disease (CD) in Sweden is about 4 cases per 1,000 people. Screening for CD with serological tests indicates similar high prevalences in many other countries. Between 1 November 1992 and 30 April 1995, 133 children (9 months to 16.7 years of age) with suspected CD were studied. The predictive value (PV) of immunoglobulin A antigliadin antibodies (IgA-AGA) in the serum as assayed with two new commercial automated immunoassays--the Pharmacia CAP System Gliadin IgA FEIA (CAP) and the UNICAP-100 (UNICAP)--and with three "in-house" methods was evaluated using assessment of the small intestinal mucosa morphology as the "gold standard." All serum samples were analyzed for total serum IgA. At presentation the diagnostic sensitivities and specificities of the different tests varied from 0.72 to 0.88 and 0.67 to 0.87, respectively. All methods showed a higher sensitivity for CD in younger children. The area under each assay's receiver operating characteristic curve was calculated and varied between 0.82 and 0.89. The positive and negative PVs for the CAP and UNICAP, which were assays with a high sensitivity and a high specificity, respectively, were estimated. In the clinically selected population (prevalence of C...Continue Reading

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Citations

May 13, 2008·The Journal of Allergy and Clinical Immunology·Stephan SteckelbroeckStefan Vieths
May 9, 2016·The Journal of Allergy and Clinical Immunology·Chrysanthi SkevakiCatherine A Thornton
Apr 28, 2006·Scandinavian Journal of Gastroenterology·Annelie CarlssonSten-A Ivarsson
Jun 6, 2006·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Raanan ShamirMoshe Leshno

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