New bioactive prenylflavonoids and dibenzocycloheptene derivative from roots of Dendrolobium lanceolatum

Journal of Natural Products
Somdej KanokmedhakulPalangpon Kongsaeree

Abstract

Two new flavanones (1 and 2), a new flavan (3), and a new rare dibenzocycloheptene derivative (4) together with a known flavan, 4'-hydroxy-2' ',2' 'dimethyl-pyranoflavan (5), were isolated from the roots of Dendrolobium lanceolatum. Their structures were established on the basis of spectral evidence, and an X-ray analysis was performed to confirm the structure of 4. Compounds 1-3 exhibited antimalarial activity with IC50 values of 2.6, 3.3, and 3.1 microg/mL, respectively. Compounds 1-5 showed moderate antimycobacterial activity with MIC values of 6.3, 12.5, 25, 25, and 50 microg/mL, respectively. In addition, 1 showed strong cytotoxicity against cancer cell lines KB, BC, and NCI-H187 with IC50 values of 1.2, 1.6, and 0.6 microg/mL, respectively, while 2 showed moderate cytotoxicity against the NCI-H187 cell line with an IC50 value of 8.1 microg/ mL.

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Citations

Dec 29, 2006·Chemistry & Biodiversity·Ying-Shu ZouGuo-Fu Zhu
Oct 28, 2006·Journal of Natural Products·Jin TatsuzakiKuo-Hsiung Lee
Oct 3, 2012·Journal of Natural Products·Hsiao-Ching Lin, Shoei-Sheng Lee
May 24, 2008·Natural Product Reports·Nigel C Veitch, Renée J Grayer
Jul 16, 2010·Journal of Asian Natural Products Research·Jian-Ping MaAi-Jun Hou
Nov 25, 2011·BMC Research Notes·Jean Bernard Lekana-DoukiFousseyni S Toure-Ndouo
Mar 24, 2015·Biochemical and Biophysical Research Communications·Jun JiHeyao Wang
Feb 13, 2015·Natural Product Research·Jing QinQin-Shi Zhao
Oct 31, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Shuaibu Babaji SanusiMuhammad Murtala Mainasara
Apr 29, 2014·Chemistry : a European Journal·Daniel PflästererA Stephen K Hashmi
Jul 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhamad Harith MazlunZunoliza Abdullah
Apr 25, 2021·Natural Products and Bioprospecting·Jian-Jun ZhaoGang Xu
Jan 9, 2020·Microbial Pathogenesis·Sharon Vieira Dos ReisAlexandre José Macedo
Nov 23, 2021·The Journal of Organic Chemistry·Chada Raji Reddy, Dattahari H Kolgave

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