New biomarkers in endometriosis

Advances in Clinical Chemistry
Larissa M CoutinhoFernando M Reis

Abstract

Endometriosis is a benign gynecological disorder which presents significant challenges in terms of diagnosis and management. Despite decades of research, there are no sufficiently sensitive and specific signs and symptoms nor blood tests for the clinical confirmation of endometriosis, which hampers prompt diagnosis and treatment. The huge majority of potential biomarkers has been discarded in research stage and very few have been translated to clinical practice. Serum CA-125 is the most studied and used one, but studies have shown its poor diagnostic performance. Several factors involved in the chronic inflammatory process of endometriosis, such as hormones, cytokines, chemokines, angiogenic factors, oxidative stress markers and others, have been implicated in the disease's pathogenesis and have been extensively studied, but not a single one has successfully been able to accurately identify the disease. MicroRNAs have emerged more recently but their utility to detect endometriosis remains uncertain. The search for a biomarker or a set of biomarkers is still open and may benefit from novel molecular biology and bioinformatics approaches to mine and uncover molecular signatures specifically associated with the disease.

Citations

Oct 1, 2019·Biomedical Reports·Rafaella PetraccoDenise Cantarelli Machado
Aug 29, 2020·Chinese Medical Journal·Zhao TianHong-Lan Zhu
Feb 23, 2020·Cell & Bioscience·Mona TaghavipourZatollah Asemi
Dec 10, 2019·Science China. Life Sciences·Lu WenZi-Jiang Chen
Feb 20, 2020·International Journal of Environmental Research and Public Health·Francisco M PeinadoFrancisco Artacho-Cordón
Apr 25, 2020·International Journal of Molecular Sciences·Alice LuddiPaola Piomboni
Jun 24, 2020·Journal of Clinical Medicine·Lutz KonradIvo Meinhold-Heerlein
Oct 13, 2019·Archives of Gynecology and Obstetrics·Yanhui Li, Qionghua Chen
Nov 7, 2020·International Journal of Molecular Sciences·Beata SmolarzHanna Romanowicz
May 7, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Mohummad Hasan Raza RajaRehana Rehman
May 6, 2021·BMJ Case Reports·Nisa Utami Ika PermatasariHenny Meitri Andrie Rachmasari Putri
May 6, 2021·International Journal of Environmental Research and Public Health·Jakub ToczekAgnieszka Drosdzol-Cop
May 20, 2021·Minerva Obstetrics and Gynecology·Maíra CasalechiFernando M Reis
Jul 3, 2021·Journal of Clinical Medicine·Żaneta Kimber-TrojnarBożena Leszczyńska-Gorzelak

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