New biotechnologies for musculoskeletal injuries

The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
Isabel Andia, Nicola Maffulli

Abstract

The practice of any sport is inherently associated with the risk of musculoskeletal lesions. We describe regenerative medicine technologies, including cellular therapies, gene therapies and multimolecular preparations of growth factors and cytokines, which are expected to advance the field of orthopaedics and sports medicine. Gene therapy involves the introduction of genetic information in the injured tissue to help that tissue to heal and, possibly, regenerate. Cell therapies used in clinical practice are based on the transplantation of adult human cells, which can be at different stages of differentiation. Currently, the stromal vascular fraction, containing stem cells and other niche components, has been injected in the articular cartilage of the knee or delivered via arthroscopy. Bone marrow concentrate (BMC) has been used to manage focal chondral defects via arthroscopy with promising clinical results. In addition, purified mesenchymal stem cells (MSCs) have been injected or delivered as an adjuvant to arthroscopic microfractures, and patients have shown improved clinical outcomes. Laboratory-expanded MSCs injected in osteoarthritis moderately improved pain and functional outcomes. MSC treatment in the form of stromal vasc...Continue Reading

Citations

Feb 16, 2019·International Journal of Molecular Sciences·Flaminia ChelliniChiara Sassoli
Jun 24, 2020·Expert Opinion on Biological Therapy·Filippo MiglioriniNicola Maffulli
Jul 17, 2020·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Esteban EstradaJavier Roberti
Jan 6, 2021·Expert Opinion on Biological Therapy·Nardeen KaderDeiary Kader
Dec 16, 2020·International Journal of Molecular Sciences·Ashim GuptaNicola Maffulli
Jan 18, 2021·British Medical Bulletin·Giuseppe GarganoNicola Maffulli
Mar 30, 2021·Frontiers in Bioengineering and Biotechnology·Maria Rita CiteroniBarbara Barboni

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