New butenolide derivatives from the marine sponge-derived fungus Aspergillus terreus

Bioorganic & Medicinal Chemistry Letters
YaTing SunHou-Wen Lin

Abstract

Two new butenolide derivatives (±)-asperteretal D ((±)-1) and asperteretal E (2) containing rare 2-benzyl-3-phenyl substituted lactone core, together with nine known analogues (3-11) were obtained from a fungus Aspergillus terreus derived from the marine sponge Phakellia fusca. All the structures were elucidated on the basis of extensive NMR spectroscopic data. The chiral chromatography analyses allowed the separation of the (±)-asperteretal D, of which the absolute configurations were determined by comparing the experimental to calculated electronic circular dichroic (ECD) spectra. Compounds (±)-1, 2-5, and 7 exhibited potent inhibitory activities against α-glucosidase with IC50 values ranging from 8.65 to 20.3 µM (positive control acarbose with an IC50 value of 320 µM). In addition, derivatives 5-8 also showed moderate antioxidant activities.

Citations

Feb 6, 2019·Natural Product Research·Qi ZengFa-Zuo Wang
Jun 9, 2019·Marine Drugs·Weiwei SunBenjamin R Clark
Feb 7, 2020·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
Aug 28, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wei WuHouwen Lin
Oct 3, 2018·Frontiers in Chemistry·Mengting LiuYonghui Zhang
Jan 5, 2021·Russian Journal of Bioorganic Chemistry·A A BaranovaA P Tyurin
Feb 22, 2021·Biomaterials·Yingbin SuYouqing Shen
Mar 30, 2021·Bioorganic & Medicinal Chemistry Letters·Patricia MoweryErin T Pelkey
Aug 27, 2021·Marine Drugs·Roberta EspositoMaria Costantini

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