PMID: 9429096Jan 16, 1998Paper

New capsule with tailored properties for the encapsulation of living cells

Journal of Biomedical Materials Research
Igor LacíkT Wang

Abstract

A new capsule for the encapsulation and transplantation of pancreatic islets has been developed. Five active ingredients are involved in the capsule formation process: high viscosity sodium alginate (SA-HV), cellulose sulfate (CS), poly(methylene-co-guanidine) hydrochloride (PMCG), calcium chloride, and sodium chloride. Complexation reaction exhibits several unique features: (1) solution of SA-HV with CS represents a physical mixture of two entangled polyanions that provide both pH-sensitive (carboxylic) and permanently charged (sulfate) groups; (2) presence of CaCl2 in the cation solution ensures formation of the gelled bead after the drop of polyanion solution is immersed in the cation solution; (3) character of the polycation (PMCG), i.e., low molecular weight and unusually high charge density, combines both high mobility and reactivity; (4) presence of PMCG in cation solution, together with CaCl2, gives rise to the competitive binding of these two cations based on their diffusion and affinity towards the anion groups; and (5) NaCl provides the anti-gelling sodium ions that significantly affect the reaction of CaCl2 with the polyanion matrix, thus altering the final properties of the capsule surface, shape, and permeability....Continue Reading

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Citations

Jan 16, 1998·Journal of Biomedical Materials Research·M BrissováT Wang
Jul 11, 1998·Journal of Biomedical Materials Research·K XuT G Wang
Dec 18, 2001·Biotechnology and Bioengineering·A V AnilkumarT G Wang
Aug 7, 2013·Advanced Drug Delivery Reviews·David W Scharp, Piero Marchetti
Nov 26, 2013·Advanced Drug Delivery Reviews·Paul de VosMarijke M Faas
Mar 22, 2005·International Journal of Pharmaceutics·S PonceJ L Pedraz
Aug 16, 2000·Advanced Drug Delivery Reviews·H UludagP A Tresco
Aug 16, 2000·Advanced Drug Delivery Reviews·B Ríhová
Jun 6, 2003·International Journal of Pharmaceutics·G OriveJ L Pedraz
Jan 3, 2006·Diabetes Technology & Therapeutics·Seda KizilelEmmanuel Opara
Feb 21, 2002·Journal of Biomaterials Science. Polymer Edition·N Angelova, D Hunkeler
Aug 9, 2003·Journal of Biomaterials Science. Polymer Edition·Shinji SakaiKoei Kawakami
Aug 27, 2009·Biologics : Targets & Therapy·Satya Prakash, Aleksandra Malgorzata Urbanska
Jul 15, 2015·Expert Opinion on Biological Therapy·Alice Anna TomeiCamillo Ricordi
Aug 13, 2002·Expert Opinion on Biological Therapy·Tejal A Desai
Nov 19, 2003·Journal of Biomedical Materials Research. Part a·C M BüngerP de Vos
Apr 21, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·In-Yong KimKyekyoon Kevin Kim
Apr 12, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rinat M IskakovTeruo Okano
Sep 8, 2004·Advanced Drug Delivery Reviews·Tejal A DesaiArfaan Rampersaud
May 4, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Martina TakacovaSilvia Pastorekova
Mar 19, 2004·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Ying YangAlicia J El Haj
Jan 19, 2002·Annals of the New York Academy of Sciences·L CanapleB Desvergne
Apr 17, 2020·ACS Applied Polymer Materials·Vincenzo CalabreseKaren J Edler
Nov 3, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Malgorzata LekkaChristine Wandrey
Oct 7, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Véronique BreguetIan W Marison

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