New challenges and promises in solid organ transplantation pharmacogenetics: the genetic variability of proteins involved in the pharmacodynamics of immunosuppressive drugs

Pharmacogenomics
Lucie PouchéNicolas Picard

Abstract

Interindividual variability in immunosuppressive drug responses might be partly explained by genetic variants in proteins involved in the immune response or associated with IS pharmacodynamics. On a general basis, the pharmacogenetics of drug target proteins is less known and understood than that of proteins involved in drug disposition pathways. The aim of this review is to facilitate research related to the pharmacodynamics of the main immunosuppressive drugs used in solid organ transplantation. We elaborated a quality of evidence grading system based on a literature review and identified 'highly recommended', 'recommended' or 'potential' candidates for further research. It is likely that a number of additional rare variants might further explain drug response phenotypes in transplantation, and particularly the most severe ones. The advent of next-generation sequencing will help to identify those variants.

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Citations

Apr 9, 2017·Clinical Pharmacology and Therapeutics·P J CaraballoR M Weinshilboum
May 3, 2019·Therapeutic Drug Monitoring·Mercè BrunetStein Bergan
Jan 25, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Brendan J KeatingBrian D Piening
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Jan 1, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Xinyi ZhengXiaoyan Qiu
Mar 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiao ZhangJinming Li

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Methods Mentioned

BETA
exome sequencing
ELISA
biopsy
genotyping

Software Mentioned

TESS
variation viewer
SNPinfo
miRanda
ESEfind
SNP
MatInspector
SOT
NODAT
Polyphen

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