PMID: 6971111Jan 1, 1981Paper

New chemotherapeutic nitroheterocycles active against 5-nitroimidazole-resistant strains of trichomonads

Arzneimittel-Forschung
J G MeingassnerH Mieth

Abstract

The synthesis and the trichomonacidal activity of some 4-substituted 2-imidazolylquinazoline derivatives are described. The new compounds were highly active against metronidazole-sensitive and metronidazole-resistant strains of trichomonads. This was demonstrated in vitro as well as in various trichomoniasis models in mice and rats after oral treatment.

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