New class of 8-aryl-7-deazaguanine cell permeable fluorescent probes

Bioorganic & Medicinal Chemistry Letters
Ilirian DhimitrukaValery V Khramtsov

Abstract

A one step synthesis of fluorescent 8-aryl-(7-deazaguanines) has been accomplished. Probes exhibit blue to green high quantum yield fluorescence in a variety of organic and aqueous solutions, high extinction coefficients, and large Stokes shifts often above 100 nm. The probes are highly cell permeable, and exhibit stable bright fluorescence once intracellular; therefore are suited to the design of biosensors.

References

May 19, 2007·Bioorganic & Medicinal Chemistry·Claudia Wanninger-WeissHans-Achim Wagenknecht
Nov 12, 2010·Journal of the American Chemical Society·Alireza OmumiRichard A Manderville
Oct 1, 2011·Organic & Biomolecular Chemistry·Lital ZilbershteinBilha Fischer

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