New classes of environmental tumor promoters: indole alkaloids and polyacetates

Environmental Health Perspectives
H FujikiR E Moore

Abstract

Tumor promoters are known to induce ODC activity in mouse skin and that this induction can be inhibited by the application of 13-cis-retinoic acid. These two properties of tumor promoters were utilized for screening new tumor promoters in our environment. Two new classes of tumor promoters are presented: indole alkaloids (teleocidin and lyngbyatoxin A) and polyacetates (aplysiatoxin and debromoaplysiatoxin). Teleocidin from streptomyces and lyngbyatoxin A, from the blue-green alga, Lyngbya majuscula, were able to induce ODC activity in mouse skin and showed various biological activities similar to those of TPA. Teleocidin and lyngbyatoxin A are indole alkaloids. Their tumor promoting activities became apparent in the mouse skin through a two-stage carcinogenicity test. The tumor incidence of the group treated with DMBA plus teleocidin was 100% at week 30, which was similar to that of the group given DMBA and TPA. The in vivo carcinogenicity test with lyngbyatoxin A is still underway. The tumor incidence of the group treated with DMBA plus lyngbyatoxin A is 80% at week 21. A second new class of tumor promoter is polyacetate. Aplysiatoxin and debromoaplysiatoxin were isolated from another variety of blue-green alga. Aplysiatoxin ...Continue Reading

References

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Citations

Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·C P RobinsonM E Bondura
Jan 1, 1984·Journal of Cancer Research and Clinical Oncology·H FujikiT Sugimura
Jul 1, 2008·Toxicon : Official Journal of the International Society on Toxinology·Kendal E HarrEdward J Phlips
Apr 14, 2016·Organic Letters·Jeremy Haynes-SmithKelvin L Billingsley
Jul 28, 2019·Archives of Toxicology·Zorica SvirčevGeoffrey A Codd
Nov 12, 1990·Biochimica Et Biophysica Acta·M WatanabeK Ohuchi
Mar 17, 1999·Journal of Natural Products·K TakahashiT Nomura

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