New Classification of Gastric Pit Patterns and Vessel Architecture Using Probe-based Confocal Laser Endomicroscopy

Journal of Clinical Gastroenterology
Zhen LiYan-qing Li

Abstract

To propose a new probe-based confocal laser endomicroscopy (pCLE) classification of gastric pit patterns and vessel architecture, and to assess the accuracy and interobserver agreement. pCLE is a newly developed endoscopic device that allows the application of laser microscopy with any conventional endoscope and mosaic imaging. A total of 291 pCLE videos from 32 patients were recruited in phase I to establish the new pCLE image classification in the stomach. Eligible patients were then prospectively investigated by pCLE using the newly established classification system. All patients were examined first with high-definition endoscopy followed by pCLE at 7 standardized locations and endoscopic-suspected lesions. Targeted biopsies were performed with precise matching of pCLE recordings. The sensitivity and specificity of type 2b pit pattern for predicting atrophic gastritis were 88.51% and 99.19%, respectively. The sensitivity and specificity of type 2c pit pattern for predicting intestinal metaplasia were 92.34% and 99.34%, respectively. The overall sensitivity and specificity of type 3 pit pattern or vessel architecture for predicting neoplasia were 89.89% and 99.44%, respectively. The interobserver agreement was "substantial" (...Continue Reading

References

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Apr 29, 2008·Gastrointestinal Endoscopy·Jian-Na ZhangHong Liu
Feb 26, 2013·Journal of Gastroenterology and Hepatology·Rapat PittayanonPinit Kullavanijaya
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Jan 11, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kenshi YaoMasahiko Tabuchi

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Citations

Mar 25, 2018·Journal of Digestive Diseases·Jing-Yuan FangUNKNOWN Chinese Society of Gastroenterology, Chinese Medical Association
Mar 20, 2020·BioMed Research International·Xiaoyun YuXiaohua Hou
May 11, 2021·World Journal of Clinical Cases·Sergey M KotelevetsSergey Z Chukov

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Methods Mentioned

BETA
biopsy
biopsies

Clinical Trials Mentioned

NCT01896310

Software Mentioned

eCLE
Scan
STATA
SPSS
pCLE
Cellvizio Viewer

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.