New classification of the shared epitope in rheumatoid arthritis: impact on the production of various anti-citrullinated protein antibodies

Rheumatology
Agnes GyetvaiGabriella Lakos

Abstract

HLA-DR [shared epitope (SE)] alleles have recently been re-classified into S1, S2, S3P and S3D groups. S2 and S3P have been associated with increased risk for RA. We assessed the impact of S1, S2, S3P and S3D alleles on anti-citrullinated protein antibody (ACPA) production. Instead of comparing allele-carriers to non-carriers, we studied each allele group individually, using the X/X (non-SE) genotype as reference. Serum and genomic DNA samples of 91 RA patients and 78 healthy controls were obtained. Various ACPAs and IgM RF were determined by ELISA. HLA-DRB1 genotyping and subtyping was performed by PCR. HLA-DRB1 alleles were re-classified as described above. Correlations between SE and ACPAs were determined. Not only S2 and S3P, but, to a lesser extent, S1 and S3D alleles also predisposed to anti-cyclic citrullinated peptide (CCP) production (P < 0.0001, P = 0.004, P = 0.01 and P = 0.027, respectively), with the following hierarchy of association: S2+S3P > S1+S3D > X/X. Similar associations were observed for anti-citrullinated vimentin. Anti-citrullinated fibrinogen (CF) exerted a different association pattern with the strongest correlation with S1 alleles [odds ratio (OR) 16.00; P = 0.05]. In addition, HLA-DRB1*15 alleles may...Continue Reading

References

Apr 20, 1978·The New England Journal of Medicine·P Stastny
Jul 22, 1998·Genetic Epidemiology·E GéninF Clerget-Darpoux
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Edward F RosloniecAndrew H Kang
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan A HillEwa Cairns
Jan 30, 2004·Genes and Immunity·J L NewtonM A Brown
Apr 9, 2005·Arthritis and Rheumatism·Sophie Tezenas du MontcelFrançoise Clerget-Darpoux
Aug 30, 2005·Annals of the New York Academy of Sciences·Anikó KapitányZoltán Szekanecz
May 2, 2006·Arthritis Research & Therapy·Laëtitia MichouUNKNOWN European Consortium on Rheumatoid Arthritis Families
Mar 1, 2008·Arthritis Research & Therapy·Thomas BarnetchePierre-Antoine Gourraud

❮ Previous
Next ❯

Citations

Feb 14, 2008·Clinical Reviews in Allergy & Immunology·Yehuda Shoenfeld, M Eric Gershwin
Feb 14, 2008·Clinical Reviews in Allergy & Immunology·Hannah Poulsom, Peter J Charles
Jan 5, 2013·Clinical Reviews in Allergy & Immunology·Júlia KurkóZoltán Szekanecz
Aug 21, 2013·Autoimmunity Reviews·Federico PratesiPaola Migliorini
May 7, 2011·Autoimmunity Reviews·Carlo PerriconeGuido Valesini
Feb 5, 2011·Arthritis Research & Therapy·Heidi KokkonenSolbritt Rantapää-Dahlqvist
Jul 17, 2013·Revista brasileira de reumatologia·Licia Maria Henrique da MotaUNKNOWN Colégio Brasileiro de Radiologia
Jun 9, 2016·Arthritis Research & Therapy·Liesbeth M De WinterVeerle Somers
Jul 15, 2016·International Journal of Rheumatic Diseases·Sami BizzariAbdul Rezzak Hamzeh
May 25, 2010·European Journal of Internal Medicine·J SchreiberR Merget
Sep 19, 2014·World Journal of Orthopedics·Izabela Korczowska
Jun 8, 2011·Nature Reviews. Rheumatology·Walther J van VenrooijGer J M Pruijn
Mar 31, 2011·Current Opinion in Rheumatology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.