New clinicopathological associations and histoprognostic markers in ILAE types of hippocampal sclerosis.

Brain Pathology
Ana Laura Calderon-GarcidueñasFranck Bielle

Abstract

Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a heterogeneous syndrome. Surgery results in seizure freedom for most pharmacoresistant patients, but the epileptic and cognitive prognosis remains variable. The 2013 International League Against Epilepsy (ILAE) histopathological classification of hippocampal sclerosis (HS) has fostered research to understand MTLE-HS heterogeneity. We investigated the associations between histopathological features (ILAE types, hypertrophic CA4 neurons, granule cell layer alterations, CD34 immunopositive cells) and clinical features (presurgical history, postsurgical outcome) in a monocentric series of 247 MTLE-HS patients treated by surgery. NeuN, GFAP and CD34 immunostainings and a double independent pathological examination were performed. 186 samples were type 1, 47 type 2, 7 type 3 and 7 samples were gliosis only but no neuronal loss (noHS). In the type 1, hypertrophic CA4 neurons were associated with a worse postsurgical outcome and granule cell layer duplication was associated with generalized seizures and episodes of status epilepticus. In the type 2, granule cell layer duplication was associated with generalized seizures. CD34+ stellate cells were more frequent in th...Continue Reading

References

Feb 1, 1997·Journal of Neuropathology and Experimental Neurology·G W MathernJ K Pretorius
Jul 21, 1999·Acta Neuropathologica·M ThomF Scaravilli
Oct 26, 1999·The Journal of Comparative Neurology·I BlümckeO D Wiestler
Mar 14, 2002·Current Rheumatology Reports·Randall W JohnsonFrank C Arnett
Jun 20, 2002·Journal of Neuropathology and Experimental Neurology·Maria ThomFrancesco Scaravilli
May 18, 2004·Epilepsia·Heinz-Gregor Wieser, UNKNOWN ILAE Commission on Neurosurgery of Epilepsy
Jan 16, 2007·Acta Neuropathologica·Ingmar BlümckeMichelle Hildebrandt
Feb 1, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Masae RyufukuAkiyoshi Kakita
Jul 6, 2012·Clinical Neuropathology·Rafael Scarpa da Costa NevesElza Márcia Targas Yacubian
Oct 4, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Gianluca MarucciMarco Giulioni
Sep 14, 2013·Frontiers in Human Neuroscience·Kim Celone Willment, Alexandra Golby
Feb 7, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Saiqun LiCarol Schuurmans
Mar 29, 2014·Frontiers in Molecular Neuroscience·Candi L Lasarge, Steve C Danzer
Apr 26, 2014·Neuropathology and Applied Neurobiology·Maria Thom
Jul 10, 2014·Acta Neuropathologica Communications·Joan LiuMaria Thom
Dec 3, 2014·Seizure : the Journal of the British Epilepsy Association·Meng NaZhiguo Lin
Jun 16, 2015·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Masaya NagaishiAkio Hyodo
Jul 15, 2015·Neurology. Neuroimmunology and Neuroinflammation·Robert L GloverAlexis Boro
Feb 24, 2016·Frontiers in Neuroscience·Marçal Vilar, Helena Mira
Aug 24, 2017·Brain Pathology·Maria ThomEleonora Aronica

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Citations

Jul 28, 2019·Neurology·Alyma SomaniMaria Thom
Apr 28, 2020·Expert Opinion on Therapeutic Targets·Phan Q DuyKristopher T Kahle
Jul 11, 2019·Brain Pathology
Apr 18, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A LeclerJ Savatovsky
Sep 29, 2019·AJNR. American Journal of Neuroradiology·A LeclerUNKNOWN ENIGMA Investigation Group (EuropeaN Interdisciplinary Group for MVNT Analysis)
Aug 9, 2019·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Eliana C de Brito ToscanoMilene A Rachid
Nov 25, 2020·Neurosurgery·Diana L Thomas, Christopher R Pierson
Nov 13, 2020·Frontiers in Neurology·Declan McGuoneOrrin Devinsky
Oct 24, 2020·Annales de pathologie·Suzanne TranFranck Bielle

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